M
Mohane Selvaraj Coumar
Researcher at Pondicherry University
Publications - 106
Citations - 2540
Mohane Selvaraj Coumar is an academic researcher from Pondicherry University. The author has contributed to research in topics: Aurora inhibitor & Virtual screening. The author has an hindex of 26, co-authored 100 publications receiving 2126 citations. Previous affiliations of Mohane Selvaraj Coumar include Panjab University, Chandigarh & Central University, India.
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Journal ArticleDOI
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
Gadarla Randheer Reddy,Ching-Chuan Kuo,Uan-Kang Tan,Mohane Selvaraj Coumar,Chi-Yen Chang,Yi-Kun Chiang,Mei-Jung Lai,Jiann-Yih Yeh,Su-Ying Wu,Jang Yang Chang,Jang Yang Chang,Jing Ping Liou,Hsing Pang Hsieh +12 more
TL;DR: A series of aroylnaphthalene derivatives were prepared as bioisosteres of combrestatin A-4 and evaluated for anticancer activity and showed strong antiproliferative activity against a panel of human cancer cell lines including multiple-drug resistant cell line.
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3D-QSAR-Assisted Drug Design: Identification of a Potent Quinazoline-Based Aurora Kinase Inhibitor
Yi Yu Ke,Hui Yi Shiao,Yung Chang Hsu,Chang Ying Chu,Wen Chieh Wang,Yen Chun Lee,Wen-Hsing Lin,Chun Hwa Chen,John T.A. Hsu,Chun Wei Chang,Cheng-Wei Lin,Teng Kuang Yeh,Yu-Sheng Chao,Mohane Selvaraj Coumar,Hsing Pang Hsieh +14 more
TL;DR: The 3D‐QSAR‐assisted design of an Aurora kinase A inhibitor with improved physicochemical properties, in’vitro activity, and in vivo pharmacokinetic profiles over those of the initial lead is described.
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2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: A Potent, Selective, and Orally Bioavailable Dipeptide-Derived Inhibitor of Dipeptidyl Peptidase IV
Hsu Tsu,Xin Chen,Chiung-Tong Chen,Shiow-Ju Lee,Chung-Nien Chang,Kuo-His Kao,Mohane Selvaraj Coumar,Yen-Ting Yeh,Chia-Hui Chien,Hsin-Sheng Wang,Ke-Ta Lin,Ying-Ying Chang,Ssu-Hui Wu,Yuan-Shou Chen,I-Lin Lu,Su-Ying Wu,Ting-Yueh Tsai,Wei Cheng Chen,Hsing Pang Hsieh,Yu-Sheng Chao,Weir-Torn Jiaang +20 more
TL;DR: The results show that compound 21a possesses in vitro and in vivo activities comparable to those of NVP-LAF237 (4), which is in clinical development.
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In-silico and in-vitro anti-cancer potential of a curcumin analogue (1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione.
Shamim Akhtar Sufi,Lakshmi Narayana Adigopula,Safiulla Basha Syed,Victor Mukherjee,Mohane Selvaraj Coumar,H. Surya Prakash Rao,Rukkumani Rajagopalan,Rukkumani Rajagopalan +7 more
TL;DR: The enhanced anti-cancer activity of a heterocyclic ring (indole) incorporated curcumin analogue, ICA, is demonstrated, indicating that ICA could hold promise to be a potential anti- cancer agent.
Journal ArticleDOI
Structural Biology Insight for the Design of Sub-type Selective Aurora Kinase Inhibitors.
TL;DR: Structural biology and computational aspects pertaining to the design of Aurora kinase inhibitors were analyzed and found that a possible means to develop sub-type selective inhibitor is by targeting Aurora A specific residues or Aurora B specific residues near the solvent exposed region of the protein.