M
Mohane Selvaraj Coumar
Researcher at Pondicherry University
Publications - 106
Citations - 2540
Mohane Selvaraj Coumar is an academic researcher from Pondicherry University. The author has contributed to research in topics: Aurora inhibitor & Virtual screening. The author has an hindex of 26, co-authored 100 publications receiving 2126 citations. Previous affiliations of Mohane Selvaraj Coumar include Panjab University, Chandigarh & Central University, India.
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Journal ArticleDOI
Optimization of Ligand and Lipophilic Efficiency To Identify an in Vivo Active Furano-Pyrimidine Aurora Kinase Inhibitor
Hui Yi Shiao,Mohane Selvaraj Coumar,Chun Wei Chang,Yi-Yu Ke,Ya-Hui Chi,Chang-Ying Chu,Hsu-Yi Sun,Chun-Hwa Chen,Wen-Hsing Lin,Ka-Shu Fung,Po-Chu Kuo,Chin-Ting Huang,Kai-Yen Chang,Cheng-Tai Lu,John T.A. Hsu,Chiung-Tong Chen,Weir-Torn Jiaang,Yu-Sheng Chao,Hsing Pang Hsieh +18 more
TL;DR: Rational optimization has led to the identification of Aurora kinase inhibitor 27 (IBPR001; LE = 0.26; LipE = 4.78), with improved in vitro potency and physicochemical properties, resulting in an in vivo active (HCT-116 colon cancer xenograft mouse model) anticancer agent.
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Drug repurposing for chronic myeloid leukemia: in silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors
Vivek Singh,Hsin Huei Chang,Ching Chuan Kuo,Hui Yi Shiao,Hsing Pang Hsieh,Mohane Selvaraj Coumar +5 more
TL;DR: In this study, structure-based and ligand-based virtual screening methods were applied to narrow down possible drugs that could target the allosteric site of Abl kinase and gefitinib was found to enhance the ability of imatinib to bind at the ATP-binding site of Bcr-Abl kinase.
Journal ArticleDOI
Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor
Mohane Selvaraj Coumar,Ming Tsung Tsai,Ming Tsung Tsai,Chang Ying Chu,Biing-Jiun Uang,Wen-Hsing Lin,Chun Yu Chang,Teng Yuan Chang,Jiun Shyang Leou,Chi Huang Teng,Jian Sung Wu,Ming Yu Fang,Chun Hwa Chen,John T.A. Hsu,John T.A. Hsu,Su Ying Wu,Yu-Sheng Chao,Hsing Pang Hsieh +17 more
TL;DR: A simple method for the identification of novel Aurora kinase A inhibitors through substructure searching of an in‐house compound library to select compounds for testing is revealed.
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BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-κB pathway--A comparative study with curcumin.
Kumaravel Mohankumar,Subhashree Sridharan,Sankar Pajaniradje,Vivek Singh,Larance Ronsard,Akhil C. Banerjea,Dinesh Babu Somasundaram,Mohane Selvaraj Coumar,Latha Periyasamy,Rukkumani Rajagopalan,Rukkumani Rajagopalan +10 more
TL;DR: Investigation of the inhibitory effects of BDMC-A, an analog of curcumin, on invasion, angiogenesis and metastasis markers using in vitro with MCF-7 cells and in silico studies proved that BD MC-A has more potential thanCurcumin.
Journal ArticleDOI
Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.
Mohane Selvaraj Coumar,Jian Sung Wu,Jiun Shyang Leou,Uan Kang Tan,Chung Yu Chang,Teng Yuan Chang,Wen-Hsing Lin,John T.A. Hsu,John T.A. Hsu,Yu-Sheng Chao,Su Ying Wu,Hsing Pang Hsieh +11 more
TL;DR: SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition.