Mohsen Ramezanpour

TL;DR: This article reviews key biophysical aspects and computational studies for several major categories of nanocarriers, including dendrimers and dendrons, polymer-, peptide-, nucleic acid-, lipid-, and carbon-based DDSs, and gold nanoparticles, and discusses how computer modeling can assist in rational design of D DSs with improved and optimized properties.

TL;DR: Evidence is presented supporting the model proposed that neutral KC2 segregates from other components and forms an amorphous oil droplet in the core of LNPs and that KC2 confinement inside the LNP may be responsible for the observed low release efficacy.

TL;DR: It is proposed that membrane binding enables bending of the αE helices, bringing the active site closer to the membrane surface, and suggesting a novel two-part auto-inhibitory mechanism for CCT involving capture of Lys122 and restraint of the pliable αE helix.

TL;DR: It is proposed that cholesterol and the degree of saturation/polyunsaturation of the lipid acyl chains, and not the lipid charge, are the main contributors in facilitating the Lα-HII phase transition and stabilizing/destabilizing the formed HII phase.

TL;DR: A general protocol for constructing computational HII systems that correspond to the experimental systems is proposed and could be used to study H II systems composed of molecules other than the PE systems used here, and to improve and validate force field parameters using the target data in HII phase.