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Showing papers by "Monica Bellei published in 2014"

Journal Article•DOI•
Omitting Radiotherapy in Early Positron Emission Tomography–Negative Stage I/II Hodgkin Lymphoma Is Associated With an Increased Risk of Early Relapse: Clinical Results of the Preplanned Interim Analysis of the Randomized EORTC/LYSA/FIL H10 Trial

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John M. M. Raemaekers1, Marc André2, Massimo Federico, Theodore Girinsky3, Reman Oumedaly, Ercole Brusamolino, Pauline Brice, Christophe Fermé3, Richard W.M. van der Maazen1, Manuel Gotti, Reda Bouabdallah, Catherine Sebban, Yolande Lievens4, Allessandro Re, Aspasia Stamatoullas, F. Morschhauser, Pieternella J. Lugtenburg5, Elisabetta Abruzzese6, Pierre Olivier, Rene-Olivier Casasnovas, Gustaaf W. van Imhoff7, Tiana Raveloarivahy8, Monica Bellei, Thierry Van der Borght2, Stéphane Bardet, Annibale Versari, Martin Hutchings9, Michel Meignan, Catherine Fortpied8 •
Radboud University Nijmegen1, Université catholique de Louvain2, Institut Gustave Roussy3, Ghent University4, Erasmus University Rotterdam5, University of Rome Tor Vergata6, Drug Abuse Resistance Education7, European Organisation for Research and Treatment of Cancer8, University of Copenhagen9
20 Apr 2014-Journal of Clinical Oncology
TL;DR: Combined-modality treatment resulted in fewer early progressions in clinical stage I/II HL, although early outcome was excellent in both arms.
Abstract: Purpose Combined-modality treatment is standard treatment for patients with clinical stage I/II Hodgkin lymphoma (HL). We hypothesized that an early positron emission tomography (PET) scan could be used to adapt treatment. Therefore, we started the randomized EORTC/LYSA/FIL Intergroup H10 trial evaluating whether involved-node radiotherapy (IN-RT) could be omitted without compromising progression-free survival in patients attaining a negative early PET scan after two cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) as compared with standard combined-modality treatment.

319 citations