M
Monica Garcia-Alloza
Researcher at University of Cádiz
Publications - 75
Citations - 6358
Monica Garcia-Alloza is an academic researcher from University of Cádiz. The author has contributed to research in topics: Senile plaques & Alzheimer's disease. The author has an hindex of 34, co-authored 71 publications receiving 5469 citations. Previous affiliations of Monica Garcia-Alloza include University of Navarra & Harvard University.
Papers
More filters
Journal ArticleDOI
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Melanie Meyer-Luehmann,Tara L. Spires-Jones,Claudia Prada,Monica Garcia-Alloza,Alix de Calignon,Anete Rozkalne,Jessica Koenigsknecht-Talboo,David M. Holtzman,Brian J. Bacskai,Bradley T. Hyman +9 more
TL;DR: It is shown that plaques form extraordinarily quickly, Within 1–2 days of a new plaque’s appearance, microglia are activated and recruited to the site, leading to increasingly dysmorphic neurites over the next days to weeks, establishing plaques as a critical mediator of neuritic pathology.
Journal ArticleDOI
Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
Robert M. Koffie,Melanie Meyer-Luehmann,Tadafumi Hashimoto,Kenneth W. Adams,Matthew L. Mielke,Monica Garcia-Alloza,Kristina D. Micheva,Stephen J. Smith,M. Leo Kim,Virginia M.-Y. Lee,Bradley T. Hyman,Tara L. Spires-Jones +11 more
TL;DR: In this article, the authors used array tomography (AT) to quantify synapse loss in Alzheimer's disease and found that senile plaques are surrounded by a halo of oligomeric forms of amyloid beta.
Journal ArticleDOI
Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease
Monica Garcia-Alloza,Elissa M. Robbins,Sandy Zhang-Nunes,Susan M. Purcell,Rebecca A. Betensky,Susan Raju,Claudia Prada,Steven M. Greenberg,Brian J. Bacskai,Matthew P. Frosch +9 more
TL;DR: The consistent and early onset of beta-amyloid accumulation in the APPswe/PS1dE9 model confirms its utility for studies of biochemical and pathological mechanisms underlying beta-AMyloid deposition, as well as exploring new therapeutic treatments.
Journal ArticleDOI
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.
TL;DR: Data suggest that curcumin reverses existing amyloid pathology and associated neurotoxicity in a mouse model of AD, which could lead to more effective clinical therapies for the prevention of oxidative stress, inflammation and neurotoxicity associated with AD.
Journal ArticleDOI
Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease
Monica Garcia-Alloza,Francisco J. Gil-Bea,Mónica Dı́ez-Ariza,Christopher Chen,Paul T. Francis,Berta Lasheras,María J. Ramírez +6 more
TL;DR: An imbalance between cholinergic-serotonergic systems may be responsible for the cognitive impairment associated to AD, and the relationships between neurochemical markers of both cholinesterase and serotonin systems and non-cognitive behavioral disturbances in patients with dementia are found.