M
Melanie Meyer-Luehmann
Researcher at University of Freiburg
Publications - 45
Citations - 6330
Melanie Meyer-Luehmann is an academic researcher from University of Freiburg. The author has contributed to research in topics: Senile plaques & Microglia. The author has an hindex of 27, co-authored 44 publications receiving 5332 citations. Previous affiliations of Melanie Meyer-Luehmann include Harvard University & German Center for Neurodegenerative Diseases.
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Journal ArticleDOI
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Melanie Meyer-Luehmann,Tara L. Spires-Jones,Claudia Prada,Monica Garcia-Alloza,Alix de Calignon,Anete Rozkalne,Jessica Koenigsknecht-Talboo,David M. Holtzman,Brian J. Bacskai,Bradley T. Hyman +9 more
TL;DR: It is shown that plaques form extraordinarily quickly, Within 1–2 days of a new plaque’s appearance, microglia are activated and recruited to the site, leading to increasingly dysmorphic neurites over the next days to weeks, establishing plaques as a critical mediator of neuritic pathology.
Journal ArticleDOI
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Melanie Meyer-Luehmann,Janaky Coomaraswamy,Tristan Bolmont,Tristan Bolmont,Stephan A. Kaeser,Claudia Schaefer,Ellen Kilger,Anton Neuenschwander,Dorothee Abramowski,Peter Frey,Anneliese L. Jaton,Jean-Marie Vigouret,Paolo Paganetti,Dominic M. Walsh,Paul M. Mathews,Jorge Ghiso,Matthias Staufenbiel,Lary C. Walker,Mathias Jucker,Mathias Jucker +19 more
TL;DR: The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Aβ strains with varying biological activities reminiscent of prion strains.
Journal ArticleDOI
Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
Robert M. Koffie,Melanie Meyer-Luehmann,Tadafumi Hashimoto,Kenneth W. Adams,Matthew L. Mielke,Monica Garcia-Alloza,Kristina D. Micheva,Stephen J. Smith,M. Leo Kim,Virginia M.-Y. Lee,Bradley T. Hyman,Tara L. Spires-Jones +11 more
TL;DR: In this article, the authors used array tomography (AT) to quantify synapse loss in Alzheimer's disease and found that senile plaques are surrounded by a halo of oligomeric forms of amyloid beta.
Journal ArticleDOI
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
Tara L. Spires,Melanie Meyer-Luehmann,Edward A. Stern,Pamela J. McLean,Jesse Skoch,Paul T. Nguyen,Brian J. Bacskai,Bradley T. Hyman +7 more
TL;DR: This work developed a method using gene transfer techniques to introduce green fluorescent protein (GFP) into neurons, allowing the investigation of neuronal processes in the vicinity of plaques, demonstrating a dramatic synaptotoxic effect of dense-cored plaques.
Journal ArticleDOI
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation
Sophia Bardehle,Martin Krüger,Felix Buggenthin,Julia Schwausch,Jovica Ninkovic,Hans Clevers,Hugo J. Snippert,Fabian J. Theis,Melanie Meyer-Luehmann,Melanie Meyer-Luehmann,Ingo Bechmann,Leda Dimou,Magdalena Götz +12 more
TL;DR: In vivo in vivo two-photon laser-scanning microscopy revealed a marked heterogeneity in the reaction of individual astrocytes, with one subset retaining their initial morphology, another directing their processes toward the lesion, and a distinct subset located at juxtavascular sites proliferating.