Mónica P. A. Ferreira

TL;DR: A spermine‐acetalated dextran‐based functional nanoparticle is developed for pH‐triggered drug delivery of two poorly water soluble small molecules capable of increasing the efficiency of direct reprogramming of fibroblast into cardiomyocytes and thus, potential cardiac regeneration therapy.

TL;DR: These FcRn-targeted NPs offer a toolbox in the development of targeted therapies for oral delivery of insulin and show high compatibility of the NPs with intestinal cells.

TL;DR: The Fc-conjugated NPs showed augmented GLP-1 permeability in an intestinal in vitro model, highlighting the potential of microfluidics as an advanced technique for the preparation of multistage platforms for oral administration.

TL;DR: The results demonstrate that the nanosystem has potential to exploit the "hitchhike" effect on M2-like macrophages and potentially improve, in a dual targeting strategy, the ability of the ANP peptide to target infarcted heart.

TL;DR: A successful method to covalently conjugate poly(methyl vinyl ether-co-maleic acid) (PMVE-MA) copolymer on the surface of (3-aminopropyl)triethoxysilane-functionalized thermally carbonized porous silicon nanoparticles (APSTCPSi NPs), forming a surface negatively charged nanovehicle with unique properties is developed.