Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip.

Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds

Spatial confinement in nanoporous media affects the structure, thermodynamics and mobility of molecular soft matter often markedly. This article reviews thermodynamic equilibrium phenomena, such as physisorption, capillary condensation, crystallisation, self-diffusion, and structural phase transitions as well as selected aspects of the emerging field of spatially confined, non-equilibrium physics, i.e. the rheology of liquids, capillarity-driven flow phenomena, and imbibition front broadening in nanoporous materials. The observations in the nanoscale systems are related to the corresponding bulk phenomenologies. The complexity of the confined molecular species is varied from simple building blocks, like noble gas atoms, normal alkanes and alcohols to liquid crystals, polymers, ionic liquids, proteins and water. Mostly, experiments with mesoporous solids of alumina, gold, carbon, silica, and silicon with pore diameters ranging from a few up to 50 nm are presented. The observed peculiarities of nanopore-confined condensed matter are also discussed with regard to applications. A particular emphasis is put on texture formation upon crystallisation in nanoporous media, a topic both of high fundamental interest and of increasing nanotechnological importance, e.g. for the synthesis of organic/inorganic hybrid materials by melt infiltration, the usage of nanoporous solids in crystal nucleation or in template-assisted electrochemical deposition of nano structures.

https://iopscience.iop.org/article/10.1088/0953-8984/27/10/103102/pdf

Soft matter in hard confinement: phase transition thermodynamics, structure, texture, diffusion and flow in nanoporous media

Spatial confinement in nanoporous media affects the structure, thermodynamics and mobility of molecular soft matter often markedly. This article reviews thermodynamic equilibrium phenomena, such as physisorption, capillary condensation, crystallisation, self-diffusion, and structural phase transitions as well as selected aspects of the emerging field of spatially confined, non-equilibrium physics, i.e. the rheology of liquids, capillarity-driven flow phenomena, and imbibition front broadening in nanoporous materials. The observations in the nanoscale systems are related to the corresponding bulk phenomenologies. The complexity of the confined molecular species is varied from simple building blocks, like noble gas atoms, normal alkanes and alcohols to liquid crystals, polymers, ionic liquids, proteins and water. Mostly, experiments with mesoporous solids of alumina, carbon, gold, silica, and silicon having pore diameters ranging from a few up to 50 nanometers are presented. The observed peculiarities of nanopore-confined condensed matter are also discussed with regard to applications. A particular emphasis is put on texture formation upon crystallisation in nanoporous media, a topic both of high fundamental interest and of increasing nanotechnological importance, e.g., for the synthesis of organic/inorganic hybrid materials by melt infiltration, the usage of nanoporous solids in crystal nucleation or in template-assisted electrochemical deposition of nano structures.

Soft matter in hard confinement: phase transition thermodynamics, structure, texture, diffusion and flow in nanoporous media - topical review

Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.202109032

In vitro Evaluation of the Therapeutic Effects of Dual-Drug Loaded Spermine-Acetalated Dextran Nanoparticles Coated with Tannic Acid for Cardiac Applications

Multifunctional Nanoparticles for Targeted Drug Delivery and Imaging for Ischemic Myocardial Injury

Spray-drying is a very well established technology, used for converting emulsions, suspensions, dispersions, or liquids into fine, dispersible particles by the use of an atomizer into a hot drying gas medium. It is a reliable and reproducible technique for particle design and tailored production, suited for a variety of applications, including drug delivery. The oral route is by far the preferred route of administration and, among other advantages, has easy-to-follow therapeutic regimens, and therefore, the highest patient compliance. Considering the myriad of advantages of advanced fabrication methods like spray-drying over conventional particle fabrication methods, the spray-drying technique holds potential in the formulation of oral drug delivery systems with improved solubility and, thereby, oral bioavailability. In this chapter, we review the principles of spray-drying, the equipment configurations used, the parameters and variables affecting particle formulation, and the main considerations for a successful industrial scale-up. We also discuss the formulation of drugs/drug delivery systems for oral administration using spray-drying, providing examples of micro/nano-particles and pure drug particles that have demonstrated the potential of this technology to overcome the limited bioavailability of drug formulations produced by other fabrication methods.

Spray-drying for the formulation of oral drug delivery systems

Drug Delivery: Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)

In spite of the incessant development in medicine and technology, cancercontinues to be one of the leading causes of death worldwide. Conventional systems for cancer therapy that are available in the market have limited and unspecific access to tumor sites. Thus, in the recent years, nanotechnology has been applied to the field of medicine, opening new avenues to the treatment, diagnosis, and monitoring of cancer diseases. This horizon has become closer with a considerable number of nano-formulations being recently approved for commercialization or reaching preclinical and clinical stages. In this context, remarkable advances in nanotechnology led to the emergence of nanodelivery systems that can specifically target an extensive variety of malignant tissues, control precisely the release of the cargos, as well as the ability to improve the biological effects of the immunostimulatory molecules via different mechanisms for cancer immunotherapy. In addition, imaging techniques combined with nanotechnology render extraordinary sensitive and powerful diagnosticand imaging tools. Multifunctional systems encompassing both therapeuticand diagnostic functions provide great advantage for tracking, in real time, the drug payloads delivered to the tumour site. The bench-to-bedside translation of the nanomedicines and technologies have introduced a new era in the design and development of innovative, but simultaneously complex targeting nanoparticles for delivery of both therapeutic and diagnostic agents to tumors. In this chapter, we focus on the current trends and developments of nanotechnology for cancer, highlighting some of the most advanced drug delivery nanosystems, targeting strategies, the nanotools used for cancer imaging and diagnostics as well as the recent nanotechnological approaches used for cancer immunotherapy.

Mónica P. A. Ferreira

Papers

In vitro Evaluation of the Therapeutic Effects of Dual-Drug Loaded Spermine-Acetalated Dextran Nanoparticles Coated with Tannic Acid for Cardiac Applications

Multifunctional Nanoparticles for Targeted Drug Delivery and Imaging for Ischemic Myocardial Injury

Spray-drying for the formulation of oral drug delivery systems

Drug Delivery: Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)

Chapter 3.5 - Current Trends and Developments for Nanotechnology in Cancer (Book Chapter)