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Patricia A. Labosky
Researcher at Vanderbilt University
Publications - 61
Citations - 12147
Patricia A. Labosky is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Neural crest & Embryonic stem cell. The author has an hindex of 42, co-authored 60 publications receiving 11632 citations. Previous affiliations of Patricia A. Labosky include University of Pennsylvania & University of Mainz.
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Journal ArticleDOI
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
TL;DR: Results provide direct genetic evidence that BMP-4 is essential for several different processes in early mouse development, beginning with gastrulation and mesoderm formation.
Journal ArticleDOI
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
Martin F. Offield,T. L. Jetton,Patricia A. Labosky,Michael Ray,Roland Stein,Mark A. Magnuson,Brigid L.M. Hogan,Christopher V.E. Wright +7 more
TL;DR: The pdx-1/beta-galactosidase fusion allele is expressed in pancreatic and duodenal cells in the absence of functional PDX-1, with expression continuing into perinatal stages with similar boundaries and expression levels, and offers additional insight into the role of p dx-1 in the determination and differentiation of the posterior foregut.
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Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
Toshihiro Ichiki,Patricia A. Labosky,Chiyo Shiota,Shigeru Okuyama,Yasuko Imagawa,Agnes B. Fogo,F Niimura,Iekuni Ichikawa,Brigid L.M. Hogan,Tadashi Inagami +9 more
TL;DR: The results show that angiotensin II activates AT1 and AT2, which have mutually counteracting haemo-dynamic effects, and that AT2 regulates central nervous system functions, including behaviour.
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HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth
Kelly L. Covello,James Kehler,Hongwei Yu,John D. Gordan,Andrew M. Arsham,Cheng-Jun Hu,Patricia A. Labosky,M. Celeste Simon,Brian Keith +8 more
TL;DR: It is indicated that HIF-2alpha can regulate stem cell function and/or differentiation through activation of Oct-4, which in turn contributes to Hif-2 alpha's tumor promoting activity.
Journal ArticleDOI
A dermal niche for multipotent adult skin-derived precursor cells
Karl J.L. Fernandes,Ian Mckenzie,Ian Mckenzie,Pleasantine Mill,Kristen M. Smith,Mahnaz Akhavan,Fanie Barnabé-Heider,Fanie Barnabé-Heider,Jeff Biernaskie,Adrienne Junek,Nao R. Kobayashi,Jean G. Toma,David R. Kaplan,Patricia A. Labosky,Victor F. Rafuse,Chi-chung Hui,Freda D. Miller +16 more
TL;DR: It is proposed that SKPs represent an endogenous embryonic precursor cell that arises in peripheral tissues such as skin during development and maintains multipotency into adulthood.