Showing papers in "Developmental Biology in 2005"

TL;DR: The conclusion follows that the liquid-like morphogenetic cell and tissue rearrangements of cell sorting, tissue spreading and segregation represent self-assembly processes guided by the diminution of adhesive-free energy as cells tend to maximize their mutual binding.

TL;DR: Fibroblast growth factors are secreted molecules which function through the activation of specific tyrosine kinases receptors, the FGF receptors that transduce the signal by activating different pathways including the Ras/MAP kinase and the phospholipase-C gamma pathways.

TL;DR: This orderly and extensive epigenetic reprogramming in premigratory and migratory germ cells might be necessary for their reacquisition of underlying totipotency, for subsequent specific epigenetic remodeling, including the resetting of parental imprints, and for the production of gametes with an appropriate epigenotype for supporting normal development.

TL;DR: A fate map of the embryonic, fetal, and postnatal heart is generated and it is shown that the endothelial and myocardial components of the outflow tract, right ventricle, and ventricular septum are derivatives of mef2c-AHF-Cre expressing cells within the anterior heart field and its derivatives.

TL;DR: The retrograde motor for IFT is required in the mouse for the phenotypic expression of both Gli activator and repressor function and for effective proteolytic processing of Gli3.

TL;DR: ociation of dimethylation but not trimethylation of H3-K9 with DNA methylation, in the female pronucleus, suggests a mechanistically significant link and begins to provide a chromatin based explanation for paternal-specific active DNA demethylation and maternal specific protection in the mouse.

TL;DR: Foxg1's position as a major regulator of telencephalic neurogenesis is reinforced and supports the idea that Foxg1 controls precursor proliferation via regulation of Fgf signaling and differentiation through regulation of Bmp signaling.

TL;DR: Recent insights into the molecular pathways regulating trophoblast lineage segregation, stem cell maintenance, and subtype differentiation are reviewed.

TL;DR: It is shown that GFR alpha-1, the receptor for GDNF (glial cell line-derived neurotrophic factor), is strongly expressed by a subset of type A spermatogonia in the basal part of the seminiferous epithelium and identified signaling pathways that may play a crucial role in maintaining germ-line stem cell proliferation and/or renewal.

TL;DR: There is now compelling evidence that, at least in mammals, FGF is required to initiate fiber differentiation and that progression of this complex process depends on the synchronized and integrated action of a number of distinct growth factor-induced signaling pathways.

TL;DR: This analysis encompasses the period between 26 and 126 h post-fertilization and follows the growth, lumen formation and differentiation of a continuous layer of endoderm into a functional intestinal epithelium with three morphologically distinct segments: the intestinal bulb, mid-intestine and posterior intestine.

TL;DR: It is shown that the secondary heart field, in addition to providing myocardium to the cardiac outflow tract, also generates prospective smooth muscle that forms the proximal walls of the aorta and pulmonary trunk.

TL;DR: Mouse oocytes control the intercellular metabolic cooperativity between cumulus cells and oocytes needed for energy production by granulosa cells and required for oocyte and follicular development.

TL;DR: The data suggest a model where scattered steroid receptor-positive cells are stem cells that self-renew through asymmetric cell division and generate patches of transit amplifying and differentiated cells.

TL;DR: The essential features of and the molecules involved in dorsoventral (DV) patterning in the neural tube are described and it is shown how complex these interactions can be.

TL;DR: Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling.

TL;DR: These studies define the major characteristics of testicular and ovarian transcriptional programs and reveal the richness of signaling processes in differentiation of the bipotential gonads into testes and ovaries.

TL;DR: It is confirmed by ex vivo cell mixing experiments that SRY is able to engage receptor-mediated signaling to up-regulate Sox9 expression and shown by employing specific inhibitors that the causative signaling molecule is prostaglandin D2 (PGD2) and that PGD2 can induce Sox9 transcription in cultured XX gonads.

TL;DR: The fate map reveals extensive morphogenetic movement of progenitors prior to tissue specification, it permits a detailed analysis of endoderm tissue patterning, and it illustrates that diverse progenitor domains can give rise to individual tissue cell types.

TL;DR: It is concluded that RA synthesized in the mesenchyme is specifically required for the normal development of the dorsal pancreatic endoderm at a stage preceding Pdx 1 function.

TL;DR: Over the past 60 years, DNA has risen from being an obscure molecule with presumed accessory or structural functions inside the nucleus to the icon of modern bioscience.

TL;DR: The data suggest a model whereby the localized expression of these genes in the posterior epiblast, and hence the formation of the primitive streak, is the result of local cell-cell interactions in the future posterior portion of the egg cylinder rather than regionalization of a radial pattern of expression in proximal epiblasts cells.

TL;DR: Data indicate that a role of Shh in the forebrain is to regulate Shh expression in the face, and that together, these Shh domains mediate patterning within the frontonasal prominence and proximodistal outgrowth of the middle and upper face.

TL;DR: Previously unappreciated derivatives of Pax3-expressing precursors in the colonic epithelium of the hindgut and within the urogenital system are detected.

TL;DR: EASE analysis reveals that genes involved in ribosome biogenesis and assembly, protein synthesis, RNA metabolism and transcription are over-represented, suggesting that genome activation during 2-cell stage may not be as global and promiscuous as previously proposed.

TL;DR: It is pointed to a general principle that self-renewal of stem cells may require a combination of maintenance of proliferation potential, inhibition of apoptosis, and blocking of differentiation, and a more balanced view of BMP signaling in regulation of stem cell properties is brought.

TL;DR: The data suggest that in mammalian development, regulation of the actin cytoskeleton by the F-actin depolymerizing factor n-cofilin is critical for epithelial-mesenchymal type of cell shape changes as well as cell proliferation.

TL;DR: Developmental competence of oocytes obtained from eCG-primed mice was substantially improved when compared to oocyte obtained from unpriming mice, and this correlated with decreased expression of genes implicated in basal transcription.

TL;DR: It is shown that beta-catenin mediated Wnt signals are required to maintain the molecular identity of the pallium by controlling expression of dorsal markers and by suppressing ventral programs from being activated in pallial progenitor cells.

TL;DR: The results show a requirement for Meis1 in the establishment of definitive hematopoiesis in the mouse embryo, which may cause the hemorrhagic phenotype.