M
Monique C. de Waard
Researcher at VU University Medical Center
Publications - 53
Citations - 2859
Monique C. de Waard is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Myocardial infarction & Enos. The author has an hindex of 27, co-authored 53 publications receiving 2499 citations. Previous affiliations of Monique C. de Waard include Erasmus University Medical Center & Leiden University Medical Center.
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Journal ArticleDOI
Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique
Caroline Cheng,Rien van Haperen,Monique C. de Waard,Luc C.A. van Damme,Dennie Tempel,Laurens Hanemaaijer,Gert W. A. van Cappellen,Joop Bos,Cornelis J. Slager,Dirk J. Duncker,Anton F. W. van der Steen,Rini de Crom,Rob Krams +12 more
TL;DR: A direct response of mRNA and protein expression in vivo to induced variations of shear stress is shown, providing the opportunity to study the relationship between shear Stress alterations, gene expression, and atherosclerosis.
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Vitamin C revisited
TL;DR: The role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure in ischemia/reperfusion or sepsis, and promoting recovery after cardiac revascularization and in critically ill patients is summarized.
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Perturbations of Vascular Homeostasis and Aortic Valve Abnormalities in Fibulin-4 Deficient Mice
Katsuhiro Hanada,Marcel Vermeij,George A. Garinis,Monique C. de Waard,Maurice G.S. Kunen,Loretha Myers,Alex Maas,Dirk J. Duncker,Carel Meijers,Harry C. Dietz,Roland Kanaar,Jeroen Essers +11 more
TL;DR: The results show that the dosage of a single gene can determine the severity of aneurysm formation and imply that disturbed TGF-&bgr; signaling underlies multiple aneurYSm phenotypes.
Journal ArticleDOI
Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.
Pleuni E. Hooijman,Albertus Beishuizen,Christian Witt,Monique C. de Waard,Armand R. J. Girbes,Angelique M. E. Spoelstra-de Man,Hans W.M. Niessen,Emmy Manders,Hieronymus W. H. van Hees,Charissa E. van den Brom,Vera Silderhuis,Michael W. Lawlor,Siegfried Labeit,Ger J.M. Stienen,Koen J. Hartemink,Marinus A. Paul,Leo M. A. Heunks,Coen A.C. Ottenheijm +17 more
TL;DR: Findings show that diaphragm muscle fibers of critically ill patients display atrophy and severe contractile weakness, and in the diphragm of critical ill patients the ubiquitin-proteasome pathway is activated.
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A novel model of cryoinjury-induced myocardial infarction in the mouse: a comparison with coronary artery ligation.
TL;DR: The results indicate that the cryoinfarction model represents the anterior myocardial infarct with modest adverse remodeling and may thus be representative forinfarcts encountered in clinical practice.