R
Roland Kanaar
Researcher at Erasmus University Rotterdam
Publications - 176
Citations - 19206
Roland Kanaar is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 70, co-authored 168 publications receiving 18043 citations. Previous affiliations of Roland Kanaar include Delft University of Technology & Erasmus University Medical Center.
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Journal ArticleDOI
Chromosomal stability and the DNA double-stranded break connection.
TL;DR: Interactions between both double-stranded break-repair pathways and other cellular processes, such as cell-cycle regulation and replication, are being unveiled.
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DNA Double-Strand Break Repair: All's Well that Ends Well
Claire Wyman,Roland Kanaar +1 more
TL;DR: It is argued that although categorizing different D SB repair mechanisms along pathways and subpathways can be conceptually useful, in cells flexible and reversible interactions among DSB repair factors form a web from which a nonpredetermined path to repair for any number of different DNA breaks will emerge.
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Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
Ate Loonstra,Marc Vooijs,H. Berna Beverloo,Bushra Al Allak,Ellen van Drunen,Roland Kanaar,Anton Berns,Jos Jonkers +7 more
TL;DR: It is described here that Cre expression in cultured mammalian cells may result in a markedly reduced proliferation and that this effect is dependent on the endonuclease activity of Cre.
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Repair of DNA interstrand cross-links.
TL;DR: The breast cancer-associated proteins Brca1 and Brca2, the Fanconi anemia-associated FANC proteins, and cell cycle checkpoint proteins are involved in regulating the cellular response to ICLs, and several models that describe possible pathways for the repair or replicational bypass of I CLs are depicted.
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Molecular mechanisms of DNA double-strand break repair
TL;DR: Recent research on the Nijmegen breakage syndrome suggests a direct link between activation of cell-cycle checkpoints and DSB repair, and the biochemical activities of proteins involved in the two major D SB repair pathways, homologous recombination and DNA end-joining, are beginning to emerge.