Moses Kizza

TL;DR: Although antenatal services were well utilised, the quality of services varied and access to essential skilled birth attendants remains difficult especially for less educated, poorer women, commonly mediated by financial and transport difficulties.

TL;DR: Neither albendazole nor praziquantel treatments affected infant response to BCG, tetanus, or measles immunisation, however, in infants of mothers with hookworm infection, albENDazole treatment reduced interleukin-5.

TL;DR: Helminth infection was not associated with more-advanced HIV disease or faster disease progression, and antihelminthic therapy may not be beneficial in slowing HIV progression in coinfected adults.

TL;DR: This trial, with a novel design comprising related interventions in pregnant women and their offspring, is the first to examine effects of helminths and their treatment in pregnancy and early childhood on immunological, infectious disease and allergic disease outcomes.

TL;DR: The hypothesis that helminth infection exacerbates HIV progression by promoting activation of 'type 2' immune responses is not supported and the possibility that chronic helmineth infection may suppress HIV replication and that effects on HIV replication may vary during helminths infection and treatment should be considered.