M
Motoko Morimoto
Researcher at Miyagi University
Publications - 53
Citations - 1408
Motoko Morimoto is an academic researcher from Miyagi University. The author has contributed to research in topics: Immune system & Small intestine. The author has an hindex of 20, co-authored 52 publications receiving 1318 citations. Previous affiliations of Motoko Morimoto include United States Department of Agriculture & Osaka City University.
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Journal ArticleDOI
Localized multigene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum.
Harry D. Dawson,Ethiopia Beshah,Sandra Mayumi Nishi,Gloria Solano-Aguilar,Motoko Morimoto,Aiping Zhao,Kathleen B. Madden,Tonya K. Ledbetter,Jitender P. Dubey,Terez Shea-Donohue,Joan K. Lunney,Joseph F. Urban +11 more
TL;DR: The use of a robust quantitative gene expression assay to detect immune and inflammatory markers at multiple host tissue sites is validated, the definition of two important swine diseases is enhanced, and the use of swine as an experimental model for the study of immunity to infectious agents relevant to humans is supported.
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Screening of Indonesian plant extracts for anti‐human immunodeficiency virus—type 1 (HIV‐1) activity
Toru Otake,Haruyo Mori,Motoko Morimoto,Noboru Ueba,Supriyatna Sutardjo,Ines Tomoco Kusumoto,Masao Hattori,Tsuneo Namba +7 more
TL;DR: Of 30 Indonesian plant extracts tested for their human immunodeficiency virus type‐1 (HIV‐1) inhibitory activities, six were shown to be effective by assays using HIV‐1‐infected MT‐4 cells: a methanol extract of mahoni and water extracts of benalu teh, which showed a significant inhibition of HIV‐ 1 protease.
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Critical Role of IL-25 in Nematode Infection-Induced Alterations in Intestinal Function
Aiping Zhao,Joseph F. Urban,Rex Sun,Jennifer A. Stiltz,Motoko Morimoto,Luigi Notari,Kathleen B. Madden,Zhonghan Yang,Viktoriya Grinchuk,Thirumalai R. Ramalingam,Thomas A. Wynn,Terez Shea-Donohue +11 more
TL;DR: IL-25 plays a critical role in nematode infection-induced alterations in intestinal function that are important for host protective immunity, and IL-13 is the major downstream Th2 cytokine responsible for the IL-25 effects.
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Peripheral CD4 T Cells Rapidly Accumulate at the Host:Parasite Interface during an Inflammatory Th2 Memory Response
Motoko Morimoto,Masahiro Morimoto,Jeannette M. Whitmire,Shiyun Xiao,Robert M. Anthony,Hiroshi Mirakami,Robert A. Star,Joseph F. Urban,William C. Gause +8 more
TL;DR: The localized immune response to a nematode parasite that encysts in the small intestine is examined, demonstrating that the Th2 memory response is readily distinguished from the primary response by the rapid accumulation of Th2 effector cells at the host:parasite interface.
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Inhibitory Effect of Tachyplesin I on the Proliferation of Human Immunodeficiency Virus in vitro
Motoko Morimoto,Haruyo Mori,Toru Otake,Noboru Ueba,Nobuharu Kunita,Makoto Niwa,Tukasa Murakami,Sadaaki Iwanaga +7 more
TL;DR: The results suggest that the anti-HIV action of tachyplesin I was due to the inhibition of virus adsorption, and that reverse transcriptase activity of HIV was not affected at concentrations of 9-80 micrograms/ml.