Muhammet Karaman

TL;DR: A series of substituted pyrazole compounds were synthesized and their structure was characterized by IR, NMR, and Mass analysis and emerged as effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms and acetylcholinesterase enzymes with Ki values in the range of 1.23-22.65 ± 5.36 µM.

TL;DR: A series of symmetrical imidazolinium chloride salts bearing secondary N-alkyl substituents were synthesized in good yield by the reaction of N,N′-dialkylethane-1,2-diamines and HC(OEt)3 in the presence of NH4Cl, characterized by spectroscopic methods.

TL;DR: Novel N-substituted rhodanine derivatives were synthesized by a green synthetic approach over one-pot reaction for inhibition effects of enzymes such as acetylcholinesterase and carbonic anhydrase as a promising approach for pharmacological intervention in a variety of disorders such as epilepsy, Alzheimer's disease and obesity.

TL;DR: The literature survey demonstrates that coumarin, 1,2-pyrazole benzothiazole, and 1,3- thiazole scaffolds are the most versatile class of molecules.

TL;DR: These obtained novel 2-methylimidazolium salts (1a-e and 2a- e) molecules were effective inhibitors of the carbonic anhydrase I and II isozymes and acetylcholinesterase (AChE) enzymes.