M
Mulugeta Million
Researcher at University of California, Los Angeles
Publications - 79
Citations - 3781
Mulugeta Million is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Receptor & Gastric emptying. The author has an hindex of 34, co-authored 75 publications receiving 3488 citations.
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Journal ArticleDOI
Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors.
TL;DR: In this paper, the activation of brain corticotropin-releasing factor (CRF) receptors mediates stress-related inhibition of upper GI and stimulation of lower GI motor function through interaction with different CRF receptor subtypes.
Journal ArticleDOI
CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome.
TL;DR: Findings implicate CRF1 receptors in stress‐related stimulation of colonic function and hypersensitivity to colorectal distention and Targeting CRf1‐dependent pathways may have potential benefit against stress or anxiety‐/depression‐related functional bowel disorders.
Journal ArticleDOI
Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats.
TL;DR: It is demonstrated that CRF acts peripherally to stimulate colonic motility and thatCRF-R1 is primarily involved in mediating IP CRF/urocortin- and water avoidance stress-induced colonic motor response.
Journal ArticleDOI
Corticotropin-Releasing Factor and the Brain-Gut Motor Response to Stress
TL;DR: Hypersecretion of CRF in the brain may contribute to the pathophysiology of stress-related exacerbation of irritable bowel syndrome.
Journal ArticleDOI
CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon.
Ekaterini Chatzaki,Paul D. Crowe,Lixin Wang,Mulugeta Million,Yvette Taché,Dimitri E. Grigoriadis +5 more
TL;DR: Results demonstrate expression of both CRF receptor types in the rat colon and support a role for their involvement in regulating peripheral effects of CRF ligands.