Munekazu Shigekawa

TL;DR: The results suggest that No.7943 has therapeutic potential as a selective blocker of excessive Ca2+ influx mediated via the Na+/Ca2+ exchanger under pathological conditions and primarily acts on external exchanger site(s) other than the transport sites in intact cells, although it is able to inhibit the exchanger from both sides of the plasma membrane.

TL;DR: Evidence that a vanilloid receptor (TRPV) homologue, TRPV2 is expressed in vascular smooth muscle cells, and that it can be activated by membrane stretch is provided.

TL;DR: RNA blot hybridization analysis with a probe specific for the cardiac ryanodine receptor mRNA shows that the stomach and brain contain a hybridizable RNA species with a size similar to that of the cardiac mRNA, which suggests that the brain contains a cardiac type of ryanode receptor mRNA.

TL;DR: Analysis of the properties of myotubes prepared from δ-sarcoglycan–deficient BIO14.6 hamsters revealed that GRC is activated in response to myocyte stretch and is responsible for enhanced Ca2+ influx and resultant cell damage as measured by creatine phosphokinase efflux, suggesting that G RC is a key player in the pathogenesis of myocyte degeneration caused by dystrophin–glycoprotein complex disruption.

TL;DR: Results suggest a mechanism by which Osorezan dace adapts to its acidic environment, and a significant role of ammonia and bicarbonate generated by glutamine catabolism is suggested.