M
Murugesan Velayutham
Researcher at University of Pittsburgh
Publications - 51
Citations - 1915
Murugesan Velayutham is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Superoxide & Chemistry. The author has an hindex of 24, co-authored 44 publications receiving 1775 citations. Previous affiliations of Murugesan Velayutham include The Ohio State University Wexner Medical Center & Johns Hopkins University.
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Journal ArticleDOI
A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal.
TL;DR: The results suggest that productive recognition of the proteolytic signal, as well as proteasome assembly and substrate unfolding, are ATP-dependent events.
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Cardiac Myocyte–Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition
Matthew B. West,Gregg Rokosh,Detlef Obal,Detlef Obal,Murugesan Velayutham,Yu-Ting Xuan,Bradford G. Hill,Rachel J. Keith,Jürgen Schrader,Yiru Guo,Daniel J. Conklin,Sumanth D. Prabhu,Jay L. Zweier,Roberto Bolli,Aruni Bhatnagar +14 more
TL;DR: Cardiomyocyte-restricted expression of iNOS provides sustained cardioprotection associated with a decrease in reperfusion-induced oxygen radicals and inhibition of mitochondrial swelling and permeability transition.
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Aldehyde oxidase functions as a superoxide generating NADH oxidase: an important redox regulated pathway of cellular oxygen radical formation.
TL;DR: Diphenyleneiodonium completely inhibited AO-mediated O(2)(•−) production, confirming that this occurs at the FAD site, and AO is predicted to have an important role in cellular redox stress and related disease pathogenesis.
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Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues.
TL;DR: Aldehyde oxidase can be an important basal source of superoxide that would be enhanced in disease settings where cellular aldehyde levels are increased, in view of the ubiquitous distribution of aldehydes in tissues.
Journal ArticleDOI
Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging.
Ilirian Dhimitruka,Murugesan Velayutham,Andrey A. Bobko,Valery V. Khramtsov,Frederick A. Villamena,Christopher M. Hadad,Jay L. Zweier +6 more
TL;DR: The large-scale synthesis of the Finland trityl radical is reported using an improved addition protocol of the aryl lithium monomer to methylchloroformate and initial applications show that the compound is very sensitive to molecular oxygen.