J. Appl. Cryst.の発刊に際して

Small-diameter (ca. 0.7 nm) single-wall carbon nanotubes are predicted to display enhanced reactivity relative to larger-diameter nanotubes due to increased curvature strain. The derivatization of these small-diameter nanotubes via electrochemical reduction of a variety of aryl diazonium salts is described. The estimated degree of functionalization is as high as one out of every 20 carbons in the nanotubes bearing a functionalized moiety. The functionalizing moieties can be removed by heating in an argon atmosphere. Nanotubes derivatized with a 4-tert-butylbenzene moiety were found to possess significantly improved solubility in organic solvents. Functionalization of the nanotubes with a molecular system that has exhibited switching and memory behavior is shown. This represents the marriage of wire-like nanotubes with molecular electronic devices.

Functionalization of carbon nanotubes by electrochemical reduction of aryl diazonium salts: a bucky paper electrode

Curved pi-conjugation, aromaticity, and the related chemistry of small fullerenes (< C60) and single-walled carbon nanotubes.

Multicomponent reactions (MCRs) are by far the most successful class of reactions leading to high structural diversity and molecular complexity through a single transformation. As part of the ongoing search for pharmacologically active lead structures, the obtained structural diversity allows for the fast exploration of a large chemical space. Not surprisingly, the development of MCRs, leading to new structural frameworks or serving as key transformations in the total synthesis of natural products, has expanded rapidly over the last few decades. To date a multitude of new three- and four-component reactions have already been described; however, examples of “higher-order” MCRs where five or even more components are combined in a single reaction vessel are remarkably scarce. This tutorial review aims to critically describe the developments achieved in recent years, charting the ideas, challenges, and milestone reactions that were essential for the progress of this field.

Higher-order multicomponent reactions: beyond four reactants.

The Infra-red Spectra of Complex Molecules.

A new domino-Knoevenagel–hetero-Diels–Alder reaction

New convenient synthesis of 2,3-diaminothieno[2,3-d]pyrimidin-4(3H)-one derivates from substituted alkyl 2-(1H-tetrazol-1-yl)thiophene-3-carboxylates

β-Keto sulfones and β-nitrile sulfones were used as building blocks for 1,2,3-triazole synthesis in the Dimroth cyclization. It was shown, that sulfone reagents undergo base-catalyzed cyclization under mild conditions (at room temperature) to give 1,2,3-triazoles in moderate to excellent yields. This fact has confirmed the high nucleophilicity of sulfonylmethylenic compounds and allows new synthetic applications.

(Arylsulfonyl)acetonesand -acetonitriles: New Activated Methylenic Building Blocks forSynthesis of 1,2,3-Triazoles

Arenediazonium tetrachlorocuprates(II). Modification of the Meerwein and Sandmeyer reactions

A convenient synthetic protocol was elaborated for creation of combinatorial libraries of 1-(R1-phenyl)-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamides. As starting materials, commercially available or readily prepared azides, amines, and diketene were selected for the reaction which has proceeded in a one-pot system with high yields and in short time.

Mykola D. Obushak

Papers

A new domino-Knoevenagel–hetero-Diels–Alder reaction

New convenient synthesis of 2,3-diaminothieno[2,3-d]pyrimidin-4(3H)-one derivates from substituted alkyl 2-(1H-tetrazol-1-yl)thiophene-3-carboxylates

(Arylsulfonyl)acetonesand -acetonitriles: New Activated Methylenic Building Blocks forSynthesis of 1,2,3-Triazoles

Arenediazonium tetrachlorocuprates(II). Modification of the Meerwein and Sandmeyer reactions

One-Pot Multicomponent Synthesis of 1-Aryl-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamides: An Easy Procedure for Combinatorial Chemistry