M
Myoung Sup Shim
Researcher at Duke University
Publications - 19
Citations - 980
Myoung Sup Shim is an academic researcher from Duke University. The author has contributed to research in topics: Retinal ganglion cell & Trabecular meshwork. The author has an hindex of 10, co-authored 17 publications receiving 803 citations. Previous affiliations of Myoung Sup Shim include University of California, San Diego.
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Journal ArticleDOI
Correction: Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration
Myoung Sup Shim,Yuji Takihara,Keunyoung Kim,Takeshi Iwata,Beatrice Y.J.T. Yue,Masaru Inatani,Robert N. Weinreb,Guy Perkins,Won-Kyu Ju +8 more
TL;DR: This Article contains an error in panel C of Figure 4, where “WT” was incorrectly written as “E50K−tg” and the correct Figure 4 appears below as Figure 1.
Journal ArticleDOI
Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma.
Dongwook Lee,Myoung Sup Shim,Keunyoung Kim,You Hyun Noh,Heemin Kim,Sang Yeop Kim,Robert N. Weinreb,Won-Kyu Ju +7 more
TL;DR: The findings suggest that CoQ10 may be a promising therapeutic strategy for ameliorating glutamate excitotoxicity and oxidative stress in glaucomatous neurodegeneration.
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Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes.
You Hyun Noh,Keunyoung Kim,Myoung Sup Shim,Soo-Ho Choi,Choi S,Mark H. Ellisman,Robert N. Weinreb,Guy Perkins,Won-Kyu Ju +8 more
TL;DR: CoQ10 may provide new therapeutic potentials and strategies for protecting ONH astrocytes against oxidative stress-mediated mitochondrial dysfunction or alteration in glaucoma and other optic neuropathies.
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DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.
Keunyoung Kim,Guy Perkins,Myoung Sup Shim,Eric A. Bushong,Alcasid N,Suyeon Ju,Mark H. Ellisman,Robert N. Weinreb,Won-Kyu Ju +8 more
TL;DR: An important vicious cycle involved in glaucomatous neurodegeneration is demonstrated that starts with elevated IOP producing oxidative stress; the oxidative stress then leads to mt fission and a specific form of mt dysfunction that generates further oxidative stress, thus perpetuating the cycle.
Journal ArticleDOI
Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury.
Dongwook Lee,Dongwook Lee,Keunyoung Kim,Myoung Sup Shim,Sang Yeop Kim,Mark H. Ellisman,Robert N. Weinreb,Won-Kyu Ju +7 more
TL;DR: In this article, a diet supplemented with CoQ10 ameliorates oxidative stress and mitochondrial alteration, as well as promotes retinal ganglion cell (RGC) survival in ischemic retina induced by intraocular pressure elevation.