M
Myriem Boufraqech
Researcher at National Institutes of Health
Publications - 42
Citations - 1623
Myriem Boufraqech is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Thyroid cancer & Cancer. The author has an hindex of 20, co-authored 41 publications receiving 1290 citations. Previous affiliations of Myriem Boufraqech include Centre national de la recherche scientifique & Institut Gustave Roussy.
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Journal ArticleDOI
ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence.
Urbain Weyemi,Odile Lagente-Chevallier,Odile Lagente-Chevallier,Myriem Boufraqech,Myriem Boufraqech,F Prenois,F Prenois,Françoise Courtin,Françoise Courtin,Bernard Caillou,Monique Talbot,M Dardalhon,M Dardalhon,A. Al Ghuzlan,Jean-Michel Bidart,Jean-Michel Bidart,Martin Schlumberger,Martin Schlumberger,Corinne Dupuy,Corinne Dupuy +19 more
TL;DR: It is reported that H-RasV12 positively regulates the NADPH oxidase system NOX4-p22phox that produces H2O2 and downregulation by siRNA abrogated H- RasV 12 regulation of CDC6 expression, an essential regulator of DNA replication.
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Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Shilpa Thakur,Brianna Daley,Kelli Gaskins,Vasyl Vasko,Myriem Boufraqech,Dhaval Patel,Carole Sourbier,Jeff M. Reece,Sheue-yann Cheng,Electron Kebebew,Sunita K. Agarwal,Joanna Klubo-Gwiezdzinska +11 more
TL;DR: It is demonstrated for the first time that MGPDH is overexpressed in thyroid cancer compared with normal thyroid, and it is established thatMGPDH regulates human thyroid cancer cell growth and OXPHOS rate in vitro.
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miR-145 suppresses thyroid cancer growth and metastasis and targets AKT3
Myriem Boufraqech,Lisa Zhang,Meenu Jain,Dhaval Patel,Ryan J. Ellis,Yin Xiong,Mei He,Naris Nilubol,Maria J. Merino,Electron Kebebew +9 more
TL;DR: The findings suggest that miR-145 is a master regulator of thyroid cancer growth, mediates its effect through the PI3K/Akt pathway, is secreted by the thyroid cancer cells, and may serve as an adjunct biomarker for thyroid cancer diagnosis.
Journal ArticleDOI
Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane.
Rodrigo S. Fortunato,Elaine Cristina Lima de Souza,Rabii Ameziane El Hassani,Myriem Boufraqech,Urbain Weyemi,Monique Talbot,Odile Lagente-Chevallier,Denise P. Carvalho,Jean Michel Bidart,Jean Michel Bidart,Martin Schlumberger,Martin Schlumberger,Corinne Dupuy +12 more
TL;DR: The DUOX-TPO association at the plasma membrane is relevant for normal enzyme properties and it is shown that TPO presents a catalase-like effect that protects DUOX from inhibition by H2O2.
Journal ArticleDOI
New Therapies for Advanced Thyroid Cancer.
TL;DR: The current understanding of the genetic alterations and the dysregulated pathways in thyroid cancer is summarized and the most recent targeted therapies and immunotherapy for advanced thyroid cancer with a promising anti-tumor activity and clinical benefit are discussed.