Corinne Dupuy

TL;DR: Microsequences permitted the cloning of porcine and human full-length cDNAs encoding, respectively, 1207- and 1210-amino acid proteins with a predicted molecular mass of 138 kDa (p138Tox), which purified from pig thyroid plasma membrane a flavoprotein which constitutes the main, if not the sole, component of the thyroid NAD(P)H oxidase.

TL;DR: It is reported that H-RasV12 positively regulates the NADPH oxidase system NOX4-p22phox that produces H2O2 and downregulation by siRNA abrogated H- RasV 12 regulation of CDC6 expression, an essential regulator of DNA replication.

TL;DR: It is demonstrated that the partially glycosylated form of Duox2, located in the endoplasmic reticulum, generates superoxide in a calcium-dependent manner and suggested that post-translational modifications during the maturation process of DuOX2 could be implicated in the mechanism of H2O2 formation by favoring intramolecular superoxide dismutation.

TL;DR: The discovery of Duox2 as a novel source of H2O2 in the digestive tract, particularly in the cecum and colon, makes it a new candidate mediator of physiopathological processes.

TL;DR: ATCs display a very dense network of interconnected RTAMs in direct contact with intermingled cancer cells, the first time that such a network is described in a malignant tumor.