U
Urbain Weyemi
Researcher at University of Texas at Austin
Publications - 28
Citations - 1490
Urbain Weyemi is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: DNA damage & NOX4. The author has an hindex of 16, co-authored 26 publications receiving 1278 citations. Previous affiliations of Urbain Weyemi include Johns Hopkins University School of Medicine & National Institutes of Health.
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Journal ArticleDOI
ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence.
Urbain Weyemi,Odile Lagente-Chevallier,Odile Lagente-Chevallier,Myriem Boufraqech,Myriem Boufraqech,F Prenois,F Prenois,Françoise Courtin,Françoise Courtin,Bernard Caillou,Monique Talbot,M Dardalhon,M Dardalhon,A. Al Ghuzlan,Jean-Michel Bidart,Jean-Michel Bidart,Martin Schlumberger,Martin Schlumberger,Corinne Dupuy,Corinne Dupuy +19 more
TL;DR: It is reported that H-RasV12 positively regulates the NADPH oxidase system NOX4-p22phox that produces H2O2 and downregulation by siRNA abrogated H- RasV 12 regulation of CDC6 expression, an essential regulator of DNA replication.
Journal ArticleDOI
Recent developments in the use of γ-H2AX as a quantitative DNA double-strand break biomarker.
Christophe E. Redon,Asako J. Nakamura,Olga A. Martin,Palak R. Parekh,Urbain Weyemi,William M. Bonner +5 more
TL;DR: The past year has seen considerable developments in the use of the DNA double-strand breaks to evaluate genome alterations in cells undergoing a variety of genotoxic stresses in vitro and in vivo, making the basic assay suitable for situations requiring great sensitivity.
Journal ArticleDOI
Tumor-associated macrophages (TAMs) form an interconnected cellular supportive network in anaplastic thyroid carcinoma.
Bernard Caillou,Monique Talbot,Urbain Weyemi,Catherine Pioche-Durieu,Abir Al Ghuzlan,Jean Michel Bidart,Salem Chouaib,Martin Schlumberger,Corinne Dupuy +8 more
TL;DR: ATCs display a very dense network of interconnected RTAMs in direct contact with intermingled cancer cells, the first time that such a network is described in a malignant tumor.
Journal ArticleDOI
Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues
Urbain Weyemi,Bernard Caillou,Monique Talbot,Monique Talbot,Rabii Ameziane-El-Hassani,Ludovic Lacroix,Odile Lagent-Chevallier,Odile Lagent-Chevallier,Odile Lagent-Chevallier,Abir Al Ghuzlan,Dirk Roos,Jean-Miche L. Bidart,Jean-Miche L. Bidart,Alai N. Virion,Alai N. Virion,Alai N. Virion,Martin Schlumberger,Martin Schlumberger,Corinne Dupuy,Corinne Dupuy,Corinne Dupuy +20 more
TL;DR: Intracellular NOX4-p22(phox) localization suggests a role in cytoplasmic redox signaling, in contrast to the DUOX localization at the apical membrane that corresponds to an extracellular H( 2)O(2) production.
Journal ArticleDOI
γ-H2AX and other histone post-translational modifications in the clinic
Christophe E. Redon,Urbain Weyemi,Palak R. Parekh,Dejun Huang,Allison S. Burrell,William M. Bonner +5 more
TL;DR: The state of the art of utilizing γ-H2AX in clinical settings is surveyed and possibilities with other histone post-translational modifications are discussed.