M
Myron Benuck
Researcher at University of York
Publications - 22
Citations - 756
Myron Benuck is an academic researcher from University of York. The author has contributed to research in topics: Enkephalin & Carboxypeptidase. The author has an hindex of 16, co-authored 22 publications receiving 751 citations.
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Enzymatic inactivation of substance P by a partially purified enzyme from rat brain.
Myron Benuck,Neville Marks +1 more
TL;DR: Sub Substance P, a unidecapeptide with potent CNS action, is rapidly inactivated by rat brain homogenate with release of all amino acids including Met.NH 2 and Leu-Met, indicating that the Arg 1 -Pro 2 bond is only slowly cleaved by brain aminopeptidases.
Journal ArticleDOI
Co-identity of brain angiotensin converting enzyme with a membrane bound dipeptidyl carboxypeptidase inactivating Met - enkephalin.
Myron Benuck,Neville Marks +1 more
TL;DR: The distribution in rat brain of angiotensin converting enzyme using hippuryl-His-Leu as substrate was identical to a dipeptidyl carboxypeptidase present in membranes assayed with Met-enkephalin as substrate.
Journal ArticleDOI
Differences in the degradation of hypothalamic releasing factors by rat and human serum.
Myron Benuck,Neville Marks +1 more
TL;DR: Rat serum is 2–5 fold more active than human serum in cleaving the three hypothalamic releasing hormones, luteinizing hormone releasing hormone (LH-RH), thyrotropin releasing hormones (TRH), and somatostatin, which correlates well with their decreased rate of degradation.
Journal ArticleDOI
Metabolic instability of myelin proteins. Breakdown of basic protein induced by brain cathepsin D.
TL;DR: This study shows that cathepsin D could be the endogenous enzyme responsible for the breakdown of basic protein to form smaller encephalitogenic fragments, some of which are known to be present in crude tissue extracts.