M
Mythily Srinivasan
Researcher at Indiana University – Purdue University Indianapolis
Publications - 41
Citations - 2474
Mythily Srinivasan is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Saliva & Experimental autoimmune encephalomyelitis. The author has an hindex of 16, co-authored 36 publications receiving 2103 citations. Previous affiliations of Mythily Srinivasan include Ohio State University.
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Effect of fixatives and tissue processing on the content and integrity of nucleic acids.
TL;DR: The purpose of this review is to provide an overview of the methods of human tissue acquisition, fixation, and preservation and the parameters of procurement and fixation that affect the quality of the tissues at the molecular level are discussed.
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Mechanisms of NF-κB p65 and strategies for therapeutic manipulation.
TL;DR: In this paper, a review of NF-κB p65-mediated signaling is presented, followed by a discussion of strategies that directly target NF-Kb p65 in the context of chronic inflammation.
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Analysis of the molecular quality of human tissues: an experience from the Cooperative Human Tissue Network.
Scott D. Jewell,Mythily Srinivasan,Linda M. McCart,Nita Williams,William H. Grizzle,Virginia A. LiVolsi,Greg MacLennan,Daniel D. Sedmak +7 more
TL;DR: The usability of nucleic acids extracted from banked human tissues for further molecular analyses was determined and gel electrophoresis was as informative as PCR, RT-PCR, and Northern blot analysis in determining the molecular usefulness of the human tissues.
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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis
TL;DR: The interplay between neuroinflammation and neurodegeneration is discussed keeping in focus NF-κB signaling as the point of convergence of multiple pathways associated with the development of the Neurodegenerative pathologies, AD and MS.
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Soluble forms of Toll‐like receptor 4 are present in human saliva and modulate tumour necrosis factor‐α secretion by macrophage‐like cells
TL;DR: The sTLR‐4 levels were elevated significantly in oral lichen planus (OLP), a chronic inflammatory condition of the oral mucosa characterized by clinical persistence, and the epithelial cells in the saliva of OLP subjects expressed significantly reduced TLR‐2 and TLR-4 mRNA that correlated with fewer bacteria/salivary epithelial Cells.