M
Myung Chul Chung
Researcher at George Mason University
Publications - 48
Citations - 958
Myung Chul Chung is an academic researcher from George Mason University. The author has contributed to research in topics: Bacillus anthracis & Trichoderma harzianum. The author has an hindex of 16, co-authored 47 publications receiving 857 citations. Previous affiliations of Myung Chul Chung include Korea Research Institute of Bioscience and Biotechnology & Kigali Institute of Science and Technology.
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Journal ArticleDOI
Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA
Gavin C. Sampey,Mohammed Saifuddin,Angela Schwab,Robert A. Barclay,Shreya Punya,Myung Chul Chung,Ramin M. Hakami,Mohammad Asad Zadeh,Benjamin Lepene,Zachary Klase,Nazira El-Hage,Mary Young,Sergey Iordanskiy,Fatah Kashanchi +13 more
TL;DR: Results imply that exosomes containing TAR RNA could directly affect the proinflammatory cytokine gene expression and may explain a possible mechanism of inflammation observed in HIV-1-infected patients under cART.
Journal ArticleDOI
Secreted neutral metalloproteases of Bacillus anthracis as candidate pathogenic factors.
Myung Chul Chung,Taissia G. Popova,Bryan Millis,Dhritiman V. Mukherjee,Weidong Zhou,Lance A. Liotta,Emanuel F. Petricoin,Vikas Chandhoke,Charles L. Bailey,Serguei G. Popov +9 more
TL;DR: It is proposed that Npr599 and InhA from B. anthracis are multifunctional pathogenic factors that may contribute to anthrax pathology through direct degradation of host tissues, increases in barrier permeability, and/or modulation of host defenses.
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The carrying pigeons of the cell: exosomes and their role in infectious diseases caused by human pathogens.
Adam Fleming,Gavin C. Sampey,Myung Chul Chung,Charles L. Bailey,Monique L. van Hoek,Fatah Kashanchi,Ramin M. Hakami +6 more
TL;DR: A synthesis of the current understanding of the role of exosomes during infections caused by human pathogens is provided and the implications of these findings for a better understanding of pathogenic mechanisms and future therapeutic and diagnostic applications are discussed.
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Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity.
Myung Chul Chung,Jessica H. Tonry,Aarthi Narayanan,Nathan P. Manes,Ryan S. Mackie,Bradford W. Gutting,Dhritiman V. Mukherjee,Taissia G. Popova,Fatah Kashanchi,Charles L. Bailey,Serguei G. Popov +10 more
TL;DR: A proteomic analysis to identify human serum proteins interacting with B. anthracis spores found that plasminogen (PLG) is a major surface-bound protein resulting in the enhancement of anti-complement and anti-opsonization properties of the pathogen.
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Degradation of Circulating von Willebrand Factor and Its Regulator ADAMTS13 Implicates Secreted Bacillus anthracis Metalloproteases in Anthrax Consumptive Coagulopathy
Myung Chul Chung,Taissia G. Popova,Shelley C. Jorgensen,Li Dong,Vikas Chandhoke,Charles L. Bailey,Serguei G. Popov +6 more
TL;DR: A new mechanism of anthrax coagulopathy affecting the levels and functional activities of both VWF and its natural regulator ADAMTS13 is suggested, which may contribute to hemorrhage and thrombosis typical in anthrax.