N
N. Collins
Researcher at Institute of Cancer Research
Publications - 26
Citations - 10028
N. Collins is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Breast cancer & Loss of heterozygosity. The author has an hindex of 23, co-authored 26 publications receiving 9697 citations. Previous affiliations of N. Collins include The Royal Marsden NHS Foundation Trust.
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Journal ArticleDOI
Androgen receptor polymorphisms: association with prostate cancer risk, relapse and overall survival.
Stephen M. Edwards,Mike Badzioch,Ralph Minter,Rifat Hamoudi,N. Collins,Audrey Ardern-Jones,A Dowe,Simon Osborne,J. Kelly,R. J. Shearer,Doug Easton,Grady F. Saunders,David P. Dearnaley,Rosalind A. Eeles +13 more
TL;DR: Since the (GGC)n effect is strongest in early‐stage tumours, this marker may help forecast aggressive behaviour and could be used to identify those patients meriting more radical treatment.
Journal Article
Detection of allelic imbalance indicates that a proportion of mammary hyperplasia of usual type are clonal, neoplastic proliferations.
TL;DR: At least a proportion of HUT thus appear to be clonal (neoplastic) rather than hyperplastic proliferations as their name suggests, and the significance of AI in the pathogenesis of H UT or its subsequent progression to carcinoma is not yet clear and requires further investigation.
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Loss of heterozygosity in ductal carcinoma in situ of the breast.
TL;DR: In a small number of cases, LOH was present in the invasive but not in the intraductal component of the tumour, suggesting that mutation at the locus concerned was associated with development of invasive behaviour.
Journal ArticleDOI
Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.
A. M. Cleton-Jansen,N. Collins,Sunil R. Lakhani,Jean Weissenbach,Peter Devilee,Cees J. Cornelisse,Michael R. Stratton +6 more
TL;DR: To investigate the involvement of BRCA2 in sporadic breast cancer 200 breast tumours were tested for LOH, and one cell line showed homozygosity in the BRC a2 region and heterozygosity at RB1, the only indication that BRCa2 is a distinct target for Loh on chromosome 13 in addition to RB1.
Journal Article
Low Frequency of Somatic Mutations in the LKB1/Peutz-Jeghers Syndrome Gene in Sporadic Breast Cancer
TL;DR: The results indicate that mutations in LKB1 do not play an important role in the development of sporadic breast cancer.