N
N Kubikova
Researcher at John Radcliffe Hospital
Publications - 14
Citations - 524
N Kubikova is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Gene & Genome editing. The author has an hindex of 6, co-authored 11 publications receiving 316 citations. Previous affiliations of N Kubikova include University of Nicosia & University of Oxford.
Papers
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Journal ArticleDOI
Genome editing reveals a role for OCT4 in human embryogenesis
Norah M. E. Fogarty,Afshan McCarthy,Kirsten E. Snijders,Benjamin E. Powell,N Kubikova,Paul Blakeley,Rebecca A. Lea,Kay Elder,Sissy E. Wamaitha,Daesik Kim,Valdone Maciulyte,Jens Kleinjung,Jin-Soo Kim,Dagan Wells,Ludovic Vallier,Ludovic Vallier,Alessandro Bertero,James M. A. Turner,Kathy K. Niakan +18 more
TL;DR: It is concluded that CRISPR–Cas9-mediated genome editing is a powerful method for investigating gene function in the context of human development.
Journal ArticleDOI
Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos
Gregorio Alanis-Lobato,Jasmin Zohren,Afshan McCarthy,Norah M. E. Fogarty,Norah M. E. Fogarty,N Kubikova,N Kubikova,Emily Hardman,Maria Greco,Dagan Wells,James M. A. Turner,Kathy K. Niakan,Kathy K. Niakan +12 more
TL;DR: The importance of further basic research to assess the safety of genome editing techniques in human embryos will inform debates about the potential clinical use of this technology, and are consistent with recent findings indicating complexity at on-target sites following CRISPR-Cas9 genome editing.
Posted ContentDOI
Frequent loss-of-heterozygosity in CRISPR-Cas9-edited early human embryos
Gregorio Alanis-Lobato,Jasmin Zohren,Afshan McCarthy,Norah M. E. Fogarty,Norah M. E. Fogarty,N Kubikova,Emily Hardman,Maria Greco,Dagan Wells,James M. A. Turner,Kathy K. Niakan,Kathy K. Niakan +11 more
TL;DR: The importance of further basic research to assess the safety of genome editing techniques in human embryos will inform debates about the potential clinical use of this technology, as well as consistent with recent findings indicating complexity at on-target sites following CRISPR-Cas9 genome editing.
Journal ArticleDOI
Clinical application of a protocol based on universal next-generation sequencing for the diagnosis of beta-thalassaemia and sickle cell anaemia in preimplantation embryos.
TL;DR: It is hoped that protocols that deliver almost universally applicable low-cost tests, without compromising diagnostic accuracy, will improve patient access to preimplantation genetic testing, especially in less affluent parts of the world.
Journal ArticleDOI
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
Elias ElInati,Agata P. Zielinska,Afshan McCarthy,N Kubikova,Valdone Maciulyte,Shantha K. Mahadevaiah,Mahesh N. Sangrithi,Mahesh N. Sangrithi,Obah A. Ojarikre,Dagan Wells,Kathy K. Niakan,Melina Schuh,James M. A. Turner +12 more
TL;DR: It is shown that the DNA-damage checkpoint eliminates oocytes via the pro-apoptotic BCL-2 pathway members Puma, Noxa and Bax , and insights are provided into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/ − oocytes.