E
Elias ElInati
Researcher at Francis Crick Institute
Publications - 13
Citations - 650
Elias ElInati is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Meiosis & Synapsis. The author has an hindex of 11, co-authored 13 publications receiving 523 citations. Previous affiliations of Elias ElInati include University of Strasbourg.
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Journal ArticleDOI
DPY19L2 deletion as a major cause of globozoospermia.
Isabelle Koscinski,Elias ElInati,Camille Fossard,Claire Redin,Jean Muller,Juan Velez de la Calle,Françoise Schmitt,Mariem Ben Khelifa,Pierre F. Ray,Pierre F. Ray,Zaid Kilani,Christopher L.R. Barratt,Stéphane Viville +12 more
TL;DR: In this article, a Jordanian consanguineous family in which five brothers were diagnosed with complete globozoospermia, showed that the four out of five analyzed infertile brothers carried a homozygous deletion of 200 kb on chromosome 12 encompassing only DPY19L2.
Journal ArticleDOI
Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots
Elias ElInati,Paul Kuentz,Claire Redin,Sara Jaber,Sara Jaber,Frauke Vanden Meerschaut,Joelle Makarian,Isabelle Koscinski,Mohammad Hossein Nasr-Esfahani,Aygul Demirol,Timur Gurgan,Noureddine Louanjli,Naeem Iqbal,Mazen Bisharah,Frédérique Carré Pigeon,Hamid Gourabi,Dominique De Briel,Florence Brugnon,Susan Gitlin,Jean-Marc Grillo,Kamran Ghaedi,M R Deemeh,Somayeh Tanhaei,Parastoo Modarres,Björn Heindryckx,Moncef Benkhalifa,Dimitra Nikiforaki,Sergio Oehninger,Petra De Sutter,Jean Muller,Stéphane Viville +30 more
TL;DR: This study confirms that DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene and should contribute to the development of an efficient molecular diagnosis strategy for globospermic patients.
Journal ArticleDOI
Assisted oocyte activation overcomes fertilization failure in globozoospermic patients regardless of the dpy19l2 status
Paul Kuentz,Paul Kuentz,F. Vanden Meerschaut,Elias ElInati,Mohammad Hossein Nasr-Esfahani,Timur Gurgan,N. Iqbal,F. Carré-Pigeon,Florence Brugnon,Susan Gitlin,J. Velez de la Calle,Zaid Kilani,P. De Sutter,Stéphane Viville +13 more
TL;DR: A pathway for the clinical management of globozoospermic patients depending on the phenotype that includes several diagnostic and therapeutic steps is proposed, with slightly better, although still very low, fertilization rates in patients carrying a DPY19L2 mutation.
Journal ArticleDOI
Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals.
Jeffrey M. Cloutier,Shantha K. Mahadevaiah,Elias ElInati,André Nussenzweig,Attila Tóth,James M. A. Turner +5 more
TL;DR: Oocyte loss cannot be explained simply by asynapsis checkpoint models, but is related to the gene content of asynapsed chromosomes, despite being enriched for γH2AFX and other checkpoint proteins.
Journal ArticleDOI
ATR is a multifunctional regulator of male mouse meiosis
Alexander Widger,Shantha K. Mahadevaiah,Julian Lange,Elias ElInati,Jasmin Zohren,Takayuki Hirota,Sarai Pacheco,Andros Maldonado-Linares,Marcello Stanzione,Obah A. Ojarikre,Valdone Maciulyte,Dirk G. de Rooij,Attila Tóth,Ignasi Roig,Scott Keeney,James M. A. Turner +15 more
TL;DR: It is demonstrated, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis, and is revealed as a critical regulator of mouse meiosis.