N
N. Li
Researcher at New York University
Publications - 4
Citations - 2032
N. Li is an academic researcher from New York University. The author has contributed to research in topics: Son of Sevenless & GRB2 Adaptor Protein. The author has an hindex of 4, co-authored 4 publications receiving 2006 citations.
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Journal ArticleDOI
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
N. Li,A. Batzer,Roger J. Daly,Vijay Yajnik,Edward Y. Skolnik,Pierre Chardin,Dafna Bar-Sagi,B. Margolis,Joseph Schlessinger +8 more
TL;DR: The results indicate that the Grbl/hSos1 complex couples activated EGF receptor to Ras signalling, and a synthetic 10-amino-acid peptide containing the sequence PPVPPR specifically blocks the interaction.
Journal ArticleDOI
The function of GRB2 in linking the insulin receptor to ras signaling pathways
Edward Y. Skolnik,A. Batzer,N. Li,Chi-Hon Lee,E. Lowenstein,Moosa Mohammadi,B. Margolis,Joseph Schlessinger +7 more
TL;DR: Insulin-induced activation of extracellular signal-regulated kinases [ERKs, also known as mitogen-activated protein (MAP) kinases] is mediated by Ras and activation of the insulin receptor results in the interaction of GRB2-Sos with IRS-1 and Shc, thus linking the insulin receptors to Ras signaling pathways.
Journal ArticleDOI
A region in Shc distinct from the SH2 domain can bind tyrosine- phosphorylated growth factor receptors
TL;DR: A novel domain is defined in Shc that has the potential to interact with growth factor receptors and other tyrosine-phosphorylated proteins.
Journal ArticleDOI
Uromodulin (Tamm-Horsfall glycoprotein/uromucoid) is a phosphatidylinositol-linked membrane protein.
TL;DR: The results indicate that THP is a member of this class of lipid-linked membrane proteins and is released into the urine after the loss of its hydrophobic anchor, probably by the action of a phospholipase or protease.