C
Chi-Hon Lee
Researcher at National Institutes of Health
Publications - 56
Citations - 6469
Chi-Hon Lee is an academic researcher from National Institutes of Health. The author has contributed to research in topics: SH2 domain & Computer science. The author has an hindex of 32, co-authored 51 publications receiving 6192 citations. Previous affiliations of Chi-Hon Lee include Howard Hughes Medical Institute & New York University.
Papers
More filters
Journal ArticleDOI
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc : implications for insulin control of ras signalling
Edward Y. Skolnik,Chi-Hon Lee,A. Batzer,Lucia M. Vicentini,M Zhou,Roger J. Daly,M J Myers,Jonathan M. Backer,A Ullrich,Morris F. White +9 more
TL;DR: A model whereby insulin stimulation leads to formation of multiple protein‐‐protein interactions between GRB2 and the two targets IRS‐1 and Shc is proposed, which may play a crucial role in activation of p21ras and the control of downstream effector molecules.
Journal ArticleDOI
Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
Ismail Moarefi,Michelle LaFevre-Bernt,Frank Sicheri,Morgan Huse,Chi-Hon Lee,John Kuriyan,John Kuriyan,W T Miller +7 more
TL;DR: It is shown that addition of the HIV-1 Nef protein, which is a high-affinity ligand for the Hck SH3 domain, to either the downregulated or activated form of Hck causes a large increase in Hck catalytic activity.
Journal ArticleDOI
The function of GRB2 in linking the insulin receptor to ras signaling pathways
Edward Y. Skolnik,A. Batzer,N. Li,Chi-Hon Lee,E. Lowenstein,Moosa Mohammadi,B. Margolis,Joseph Schlessinger +7 more
TL;DR: Insulin-induced activation of extracellular signal-regulated kinases [ERKs, also known as mitogen-activated protein (MAP) kinases] is mediated by Ras and activation of the insulin receptor results in the interaction of GRB2-Sos with IRS-1 and Shc, thus linking the insulin receptors to Ras signaling pathways.
Journal ArticleDOI
Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain
TL;DR: The crystal structure of the conserved core of HIV-1 Nef has been determined in complex with the SH3 domain of a mutant Fyn tyrosine kinase (a single amino acid substitution, Arg-96 to isoleucine), to which Nef binds tightly.
Journal ArticleDOI
A Presynaptic Gain Control Mechanism Fine-Tunes Olfactory Behavior
Cory M. Root,Kaoru Masuyama,David S. Green,Lina E. Enell,Dick R. Nässel,Chi-Hon Lee,Jing W. Wang +6 more
TL;DR: Findings indicate that different olfactory receptor channels employ heterogeneous presynaptic gain control as a mechanism to allow an animal's innate behavioral responses to match its ecological needs.