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N.P.J. Day
Researcher at University of Oxford
Publications - 19
Citations - 1167
N.P.J. Day is an academic researcher from University of Oxford. The author has contributed to research in topics: Detection limit & High-performance liquid chromatography. The author has an hindex of 15, co-authored 19 publications receiving 1118 citations. Previous affiliations of N.P.J. Day include John Radcliffe Hospital & Mahidol University.
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Journal ArticleDOI
Fluid Replacement in Dengue Shock Syndrome: A Randomized, Double-Blind Comparison of Four Intravenous-Fluid Regimens
Nguyen Minh Dung,N.P.J. Day,Dong Thi Hoai Tam,Huynh Thi Loan,H. T. T. Chau,L. N. Minh,Tran Vinh Diet,D. B. Bethell,Rachel Kneen,Tran Tinh Hien,N J White,Jeremy Farrar +11 more
TL;DR: A double-blind, randomized trial comparing four intravenous-fluid regimens for acute resuscitation of 50 children with DSS found that Dextran 70 provided the most rapid normalization of the hematocrit and restoration of the cardiac index, without adverse effects, and may be the preferred solution for urgent resuscitation in DSS.
Journal ArticleDOI
Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate for matrix effects.
TL;DR: A bioanalytical method for the analysis of piperaquine in human plasma using off-line solid-phase extraction and liquid chromatography coupled to positive tandem mass spectroscopy has been developed and validated and it was found that a mobile phase with high pH led to better sensitivity than mobile phase combinations with low pH.
Journal ArticleDOI
Age-related changes in microvascular permeability: a significant factor in the susceptibility of children to shock?
J. Gamble,D. Bethell,N.P.J. Day,Pham Phu Loc,N. H. Phu,I. B. Gartside,J. F. Farrar,Nicholas J. White +7 more
TL;DR: Factors may explain why children more readily develop hypovolaemic shock than adults in dengue haemorrhagic fever and other conditions characterized by increased microvascular permeability, which is known to be more permeable to water and plasma proteins than when mature.
Journal ArticleDOI
A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria
Kasia Stepniewska,N.P.J. Day,A Babiker,David G. Lalloo,David A. Warrell,Piero Olliaro,Nicholas J. White,Artemether-Quinine Meta-anal Study +7 more
TL;DR: In the treatment of severe falciparum malaria artemether is at least as effective as quinine in terms of mortality and superior to quInine interms of overall serious adverse events, and there was no evidence of clinical neurotoxicity or any other major side-effects associated with its use.
Journal ArticleDOI
Blood-brain barrier function in cerebral malaria and CNS infections in Vietnam.
Hc C. Brown,Tt T. H. Chau,Nt T. H. Mai,N.P.J. Day,Dx X. Sinh,Nj J. White,Tt T. Hien,Jj J. Farrar,Gd D. H. Turner +8 more
TL;DR: CM appears to involve only subtle functional changes in BBB integrity with minimal intraparenchymal inflammatory responses compared with other neurologic infections.