Pham Phu Loc

TL;DR: Elevated plasma cytokines in severe malaria are associated with systemic pathologic abnormalities, not cerebral involvement, and both the overall magnitude of the cytokine responses and the eventual imbalance between the pro- and antiinflammatory responses are important determinants of mortality.

TL;DR: Hemofiltration is superior to peritoneal dialysis in the treatment of infection-associated acute renal failure and the cost per life saved was less than one third.

TL;DR: Patients infected with the malaria parasite Plasmodium falciparum may develop a diffuse reversible encephalopathy, termed cerebral malaria, which is unclear how the intraerythrocytic parasite induces this neurological syndrome.

TL;DR: Intensified antituberculosis treatment was not associated with a higher rate of survival among patients with tuberculous meningitis than standard treatment and there were no significant differences in secondary outcomes between the treatment groups.

TL;DR: The results confirm the importance of acidosis in the pathophysiology of severe adult malaria and suggest a multifactorial origin involving tissue hypoxia, liver dysfunction, and impaired renal handling of bicarbonate.