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N. T. Moldogazieva
Researcher at I.M. Sechenov First Moscow State Medical University
Publications - 30
Citations - 941
N. T. Moldogazieva is an academic researcher from I.M. Sechenov First Moscow State Medical University. The author has contributed to research in topics: Alpha-fetoprotein & Oxidative stress. The author has an hindex of 9, co-authored 27 publications receiving 536 citations. Previous affiliations of N. T. Moldogazieva include Russian National Research Medical University.
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Journal ArticleDOI
Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases.
N. T. Moldogazieva,Innokenty M. Mokhosoev,Innokenty M. Mokhosoev,Tatiana I Melnikova,Yuri B. Porozov,Alexander A Terentiev +5 more
TL;DR: Experimental data evidencing the impairment in cellular functions caused by AGE/ALE accumulation under oxidative stress conditions are discussed to demonstrate that the identification of cellular dysfunctions involved in disease initiation and progression can serve as a basis for the discovery of relevant therapeutic agents.
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ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications.
TL;DR: Recent advances in investigation of mechanisms of protein redox modifications and adaptive redox switches such as MAPK/PI3K/PTEN, Nrf2/Keap1, and NF-κB/IκB, powerful regulators of numerous physiological processes, also implicated in various diseases are discussed.
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Reactive Oxygen and Nitrogen Species–Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy
TL;DR: This review focuses on the latest advancements evidencing that RONS-induced modifications of key redox-sensitive residues in regulatory proteins, that is, cysteine oxidation/S-sulfenylation/ S-glutathionylation /S-nitrosylation and tyrosine nitration, represent important molecular mechanisms underlying carcinogenesis.
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Alpha-fetoprotein: a renaissance
TL;DR: A review summarizes efforts of different scientific groups throughout the world in studying AFP for 50 years with emphasis on detailed description of recent achievements in this field.
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Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK
TL;DR: The present review focuses on cross-talks between HIF-1, glucose transporters, and AMPK with other regulatory proteins including oncogenes such as c-Myc, p53, and KRAS; growth factor-initiated protein kinase B (PKB)/Akt, phosphatidyl-3-kinase (PI3K), and mTOR signaling pathways; and tumor suppressors in controlling cancer cell metabolism.