Na Li

TL;DR: It is shown that methane-rich saline (MS) ip treatment alleviated endotoxin shock, bacteria-induced sepsis and dextran-sulfate-sodium-induced colitis in mice via decreased production of TNF-α and IL-6 and resulted in markedly enhanced phosphorylation of GSK-3β and AKT, which both mediate the release of Il-10.

TL;DR: It is suggested that inhibition of P2Y2 receptors leads to down-regulation of ERK-mediated phosphorylation and increase of the expression of IA–related Kv channels in trigeminal ganglion neurons, which might contribute to the clinical treatment of trigemINAL neuropathic pain.

TL;DR: The results indicate the important involvement of mainly ERK and p38 MAPK pathways in modulating BKCa channels in ION-CCI TG neurons, and represent a new therapeutic target for the clinical treatment of trigeminal neuropathic pain.

TL;DR: UHPLC-Q-TOFMS-based metabolomics approach provided a better understanding of PBDEs-induced toxicity dynamically and revealed several pathways including Tyrosine metabolism, Purine metabolism and Riboflavin metabolism, which may give a possible explanation for the toxic mechanism of BDE-3.

TL;DR: The data provide evidence that MS may activate the PI3K–AKT–GSK-3β pathway to induce IL-10 expression and produce anti-inflammatory effects via the NF-κB and MAPK pathways and provide a new pharmacological strategy for management of inflammatory response after acute liver injury.