N
Na Sun
Researcher at Ludwig Maximilian University of Munich
Publications - 60
Citations - 1027
Na Sun is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 13, co-authored 33 publications receiving 629 citations.
Papers
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Journal ArticleDOI
High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue
Alice Ly,Achim Buck,Benjamin Balluff,Na Sun,Karin Gorzolka,Annette Feuchtinger,Klaus-Peter Janssen,Peter J. K. Kuppen,Cornelis J.H. van de Velde,Gregor Weirich,Franziska Erlmeier,Rupert Langer,Michaela Aubele,Horst Zitzelsberger,Liam A. McDonnell,Michaela Aichler,Axel Walch +16 more
TL;DR: A protocol for the in situ analysis of metabolite content from FFPE samples using a high-mass-resolution matrix-assisted laser desorption/ionization fourier-transform ion cyclotron resonance mass spectrometry imaging (MALDI-FT-ICR-MSI) platform is presented.
Journal ArticleDOI
High-resolution MALDI-FT-ICR MS imaging for the analysis of metabolites from formalin-fixed, paraffin-embedded clinical tissue samples.
Achim Buck,Alice Ly,Benjamin Balluff,Na Sun,Karin Gorzolka,Annette Feuchtinger,Klaus-Peter Janssen,Peter J. K. Kuppen,Cornelis J.H. van de Velde,Gregor Weirich,Franziska Erlmeier,Rupert Langer,Michaela Aubele,Horst Zitzelsberger,Michaela Aichler,Axel Walch +15 more
TL;DR: The first analytical approach to demonstrate the in situ imaging of metabolites from formalin‐fixed, paraffin‐embedded (FFPE) human tissue samples using high‐resolution matrix‐assisted laser desorption/ionization Fourier‐transform ion cyclotron resonance mass spectrometry imaging (MALDI‐FT‐ICR MSI) is presented.
Journal ArticleDOI
N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes
Michaela Aichler,Daniela Borgmann,Jan Krumsiek,Achim Buck,Patrick E. MacDonald,Jocelyn E. Manning Fox,James Lyon,Peter E. Light,Susanne Keipert,Martin Jastroch,Annette Feuchtinger,Nikola S. Mueller,Na Sun,Andrew Palmer,Theodore Alexandrov,Theodore Alexandrov,Martin Hrabé de Angelis,Susanne Neschen,Matthias H. Tschöp,Axel Walch +19 more
TL;DR: β cell dysfunction results from enhanced insulin secretion combined with an arrest of insulin synthesis and energy deficiency via excessive β-oxidation and depletion of TCA cycle and oxidative phosphorylation metabolites.
Journal ArticleDOI
Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels
Na Sun,Axel Walch +1 more
TL;DR: In this review, qualitative and quantitative MSI of drugs and metabolites in tissue at therapeutic levels are discussed and the impact of this technique in drug discovery and clinical research is highlighted.
Journal ArticleDOI
Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging
TL;DR: This is the first pharmacokinetic study to investigate the tissue distribution of orally administered pirfenidone and its related metabolites simultaneously in organs without labeling and found 129 discriminative m/z values which represent clear differences between control and treated lungs, the majority of which are currently unknown.