M
Matthias H. Tschöp
Researcher at Technische Universität München
Publications - 440
Citations - 48795
Matthias H. Tschöp is an academic researcher from Technische Universität München. The author has contributed to research in topics: Ghrelin & Receptor. The author has an hindex of 95, co-authored 422 publications receiving 43273 citations. Previous affiliations of Matthias H. Tschöp include Martin Luther University of Halle-Wittenberg & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Ghrelin induces adiposity in rodents.
TL;DR: It is proposed that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary, suggesting an involvement in regulation of energy balance.
Journal ArticleDOI
Circulating Ghrelin Levels Are Decreased in Human Obesity
Matthias H. Tschöp,Christian Weyer,P. Antonio Tataranni,Viswanath Devanarayan,Eric Ravussin,Mark L. Heiman +5 more
TL;DR: Plasma ghrelin concentration was decreased in obese Caucasians as compared with lean Caucasians and was lower in Pima Indians, a population with a very high prevalence of obesity, compared with Caucasians.
Journal ArticleDOI
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Michael A. Cowley,Roy G. Smith,Sabrina Diano,Matthias H. Tschöp,Nina Pronchuk,Kevin L. Grove,Christian J. Strasburger,Martin Bidlingmaier,Michael Esterman,Mark L. Heiman,Luis M. Garcia-Segura,Eduardo A. Nillni,Pablo Mendez,Malcolm J. Low,Péter Sótonyi,Jeffrey M. Friedman,Hongyan Liu,Shirly Pinto,William F. Colmers,Roger D. Cone,Tamas L. Horvath +20 more
TL;DR: Using electrophysiological recordings, ghrelin stimulated the activity of arcuate NPY neurons and mimicked the effect of NPY in the paraventricular nucleus of the hypothalamus (PVH), thus representing a novel regulatory circuit controlling energy homeostasis.
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Obesity is associated with hypothalamic injury in rodents and humans
Joshua P. Thaler,Chun-Xia Yi,Ellen A. Schur,Stephan J. Guyenet,Bang H. Hwang,Marcelo O. Dietrich,Xiaolin Zhao,David A. Sarruf,Vitaly Izgur,Kenneth R. Maravilla,Hong T. Nguyen,Jonathan D. Fischer,Miles E. Matsen,Brent E. Wisse,Gregory J. Morton,Tamas L. Horvath,Denis G. Baskin,Matthias H. Tschöp,Michael W. Schwartz +18 more
TL;DR: Obesity is associated with neuronal injury in a brain area crucial for body weight control in both humans and rodent models, and evidence of increased gliosis in the mediobasal hypothalamus of obese humans is found.
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Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.
TL;DR: Ghrelin is considered a gastrointestinal peptide contributing to the regulation of diverse functions of the gut-brain axis and there is indeed a possibility that ghrelin analogs, acting as either agonists or antagonists, might have clinical impact.