Naama Elefant

TL;DR: This study raises the proportion of clustered human miRNAs that are <3000 nt apart to 42%.

TL;DR: In this paper, the authors developed an algorithm for the prediction of miRNA targets and applied it to human cytomegalovirus miRNAs, resulting in the identification of the major histocompatibility complex class I-related chain B (MICB) gene as a top candidate target of hcmv-miR-UL112.

TL;DR: During subacute infection of a mutant mouse cytomegalovirus lacking two viral miRNAs, virus production is selectively reduced in salivary glands, an organ essential for virus persistence and horizontal transmission, pointing towards a miRNA-based immunoevasion mechanism important for long-term virus persistence.

TL;DR: A new database offering miRNA target predictions of several binding types, identified by the recently developed modular algorithm RepTar, which contains genome-wide predictions of human and mouse miRNAs as well as predictions of cellular targets of the less evolutionarily conserved viral mi RNAs.

TL;DR: Analyzing the cellular targets of viral miRNAs, it is shown that viral mi RNAs use various binding patterns to exploit cellular miRNA binding sites and suggest roles for these targets in virus-host interactions.