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Simcha Yagel
Researcher at Hebrew University of Jerusalem
Publications - 408
Citations - 13762
Simcha Yagel is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Pregnancy & Medicine. The author has an hindex of 56, co-authored 379 publications receiving 12083 citations. Previous affiliations of Simcha Yagel include Shaare Zedek Medical Center & Hadassah Medical Center.
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Journal ArticleDOI
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
Jacob H. Hanna,Debra Goldman-Wohl,Yaron Hamani,Inbal Avraham,Caryn Greenfield,Shira Natanson-Yaron,Diana Prus,Leonor Cohen-Daniel,Tal I. Arnon,Irit Manaster,Roi Gazit,Vladimir Yutkin,Daniel Benharroch,Angel Porgador,Eli Keshet,Simcha Yagel,Ofer Mandelboim +16 more
TL;DR: It is shown that dNK cells, but not peripheral blood–derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein–10 chemokines.
Journal ArticleDOI
Host immune system gene targeting by a viral miRNA.
Noam Stern-Ginossar,Naama Elefant,Albert Zimmermann,Dana G. Wolf,Nivin Saleh,Moshe Biton,Elad Horwitz,Zafnat Prokocimer,Mark N. Prichard,Gabriele Hahn,Debra Goldman-Wohl,Caryn Greenfield,Simcha Yagel,Hartmut Hengel,Yael Altuvia,Hanah Margalit,Ofer Mandelboim +16 more
TL;DR: In this paper, the authors developed an algorithm for the prediction of miRNA targets and applied it to human cytomegalovirus miRNAs, resulting in the identification of the major histocompatibility complex class I-related chain B (MICB) gene as a top candidate target of hcmv-miR-UL112.
Journal ArticleDOI
CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells.
Jacob H. Hanna,Ori Wald,Debra Goldman-Wohl,Diana Prus,Gal Markel,Roi Gazit,Gil Katz,Ronit Haimov-Kochman,Nobutaka Fujii,Simcha Yagel,Amnon Peled,Ofer Mandelboim +11 more
TL;DR: It is demonstrated in vivo that invading EVTs that eventually perform endovascular invasion express CXCL12, the ligand for CXCR4, but not ligands forCXCR3, and that these receptors are involved in migration of all NK subsets to their ligands.
Journal ArticleDOI
Congenital Heart Defects Natural Course and In Utero Development
Simcha Yagel,Ariel Weissman,Zeev Rotstein,Moshe Manor,Julius Hegesh,Eyal Y. Anteby,Shlomo Lipitz,Reuwen Achiron +7 more
TL;DR: Although most fetal cardiac anomalies are detectable early in gestation, some may evolve in utero at different stages of pregnancy.
Journal ArticleDOI
Examination of the fetal heart by five short-axis views: a proposed screening method for comprehensive cardiac evaluation.
TL;DR: Fetal cardiac malformations, with an incidence of 8 : 1000among livebirths, are the most common congenital malforma-tions, and their incidence is 6.5 times greater than chromosomalanomalies and 4 times that of neural tube defects.