抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Preface to the Princeton Landmarks in Biology Edition vii Preface xi Symbols Used xiii 1. The Importance of Islands 3 2. Area and Number of Speicies 8 3. Further Explanations of the Area-Diversity Pattern 19 4. The Strategy of Colonization 68 5. Invasibility and the Variable Niche 94 6. Stepping Stones and Biotic Exchange 123 7. Evolutionary Changes Following Colonization 145 8. Prospect 181 Glossary 185 References 193 Index 201

The Theory of Island Biogeography

N G van Kampen 1981 Amsterdam: North-Holland xiv + 419 pp price Dfl 180 This is a book which, at a lower price, could be expected to become an essential part of the library of every physical scientist concerned with problems involving fluctuations and stochastic processes, as well as those who just enjoy a beautifully written book. It provides an extensive graduate-level introduction which is clear, cautious, interesting and readable.

https://iopscience.iop.org/article/10.1088/0031-9112/34/4/040/pdf

Stochastic Processes in Physics and Chemistry

Complex networks arise in a wide range of biological and sociotechnical systems. Epidemic spreading is central to our understanding of dynamical processes in complex networks, and is of interest to physicists, mathematicians, epidemiologists, and computer and social scientists. This review presents the main results and paradigmatic models in infectious disease modeling and generalized social contagion processes.

Epidemic processes in complex networks

I. the origin of species by means of natural selection

Population dynamics reflects an underlying birth-death process, where the rates associated with different events may depend on external environmental conditions and on the population density. A whole family of simple and popular deterministic models (such as logistic growth) supports a transcritical bifurcation point between an extinction phase and an active phase. Here we provide a comprehensive analysis of the phases of that system, taking into account both the endogenous demographic noise (random birth and death events) and the effect of environmental stochasticity that causes variations in birth and death rates. Three phases are identified: in the inactive phase the mean time to extinction $T$ is independent of the carrying capacity $N$ and scales logarithmically with the initial population size. In the power-law phase $T\ensuremath{\sim}{N}^{q}$, and in the exponential phase $T\ensuremath{\sim}exp(\ensuremath{\alpha}N)$. All three phases and the transitions between them are studied in detail. The breakdown of the continuum approximation is identified inside the power-law phase, and the accompanying changes in decline modes are analyzed. The applicability of the emerging picture to the analysis of ecological time series and to the management of conservation efforts is briefly discussed.

Comprehensive phase diagram for logistic populations in fluctuating environment.

In many natural situations, one observes a local system with many competing species that is coupled by weak immigration to a regional species pool. The dynamics of such a system is dominated by its stable and uninvadable (SU) states. When the competition matrix is random, the number of SUs depends on the average value and variance of its entries. Here we consider the problem in the limit of weak competition and large variance. Using a yes-no interaction model, we show that the number of SUs corresponds to the number of maximum cliques in an Erdos-Renyi network. The number of SUs grows exponentially with the number of species in this limit, unless the network is completely asymmetric. In the asymmetric limit, the number of SUs is O(1). Numerical simulations suggest that these results are valid for models with a continuous distribution of competition terms.

Alternative steady states in ecological networks.

Stochastic logistic-type growth on a static heterogeneous substrate is studied both above and below the drift-induced delocalization transition. Using agent-based simulations, the delocalization of the highest eigenfunction of the deterministic operator is connected with the large N limit of the stochastic theory. It is seen that the localization length of the deterministic theory controls the divergence of the spatial correlation length with N at the transition. It is argued that, in the presence of a strong wind, the extinction transition belongs to the directed percolation universality class, as any finite colony made of discrete agents is washed away from a heterogeneity with compact support. Some of the difficulties in the analysis of the extinction transition in the presence of a weak wind, where there is a localized active state, are discussed.

The effect of spatial heterogeneity on the extinction transition in stochastic population dynamics

In a system of interdependent networks, an initial failure of nodes invokes a cascade of iterative failures that may lead to a total collapse of the whole system in a form of an abrupt first order transition. When the fraction of initial failed nodes $1-p$ reaches criticality, $p=p_c$, the abrupt collapse occurs by spontaneous cascading failures. At this stage, the giant component decreases slowly in a plateau form and the number of iterations in the cascade, $\tau$, diverges. The origin of this plateau and its increasing with the size of the system remained unclear. Here we find that simultaneously with the abrupt first order transition a spontaneous second order percolation occurs during the cascade of iterative failures. This sheds light on the origin of the plateau and on how its length scales with the size of the system. Understanding the critical nature of the dynamical process of cascading failures may be useful for designing strategies for preventing and mitigating catastrophic collapses.

Simultaneous first and second order percolation transitions in interdependent networks

We present a new method to describe time series with a highly complex time evolution. The time series is projected onto a two-dimensional phase–space plot which is quantified in terms of a multipole expansion where every data point is assigned a unit mass. The multipoles provide an efficient characterization of the original time series.

Nadav M. Shnerb

Papers

Comprehensive phase diagram for logistic populations in fluctuating environment.

Alternative steady states in ecological networks.

The effect of spatial heterogeneity on the extinction transition in stochastic population dynamics

Simultaneous first and second order percolation transitions in interdependent networks

Description of complex time series by multipoles