Nadia Yasmín Edelsztein

TL;DR: Serum AMH measurements are useful, together with testosterone determination, in the diagnosis of patients with ambiguous genitalia: both are low in patients with gonadal dysgenesis, including ovotesticular disorders of sex development, testosterone is low but AMH is in the normal male range or higher in Patients with disorders of androgen synthesis, and both hormones are normal or high in patientswith androgen insensitivity.

TL;DR: This review focuses on the molecular mechanisms that underlie anti-Müllerian hormone inhibition by androgens at puberty, as well as on the role androgens have on Sertoli cell tight junction formation and maintenance and, consequently, on its effect on proper germ cell differentiation and meiotic onset during spermatogenesis.

TL;DR: The mechanism behind AMH inhibition by androgens, as seen in physiological and pathological conditions in males, is described for the first time.

TL;DR: Evidence presented here provides biological plausibility to the hypothesis that testicular AMH production increases in clinical conditions in response to elevated oestrogen levels.

TL;DR: The reported decline in CYP26B1 expression in Sertoli cells towards pubertal onset does not appear to be caused by a direct inhibitory effect of androgens on SERToli cells in the mouse.