THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

The Design and Analysis of Experiments

Multiple imputation by chained equations is a flexible and practical approach to handling missing data. We describe the principles of the method and show how to impute categorical and quantitative variables, including skewed variables. We give guidance on how to specify the imputation model and how many imputations are needed. We describe the practical analysis of multiply imputed data, including model building and model checking. We stress the limitations of the method and discuss the possible pitfalls. We illustrate the ideas using a data set in mental health, giving Stata code fragments. Copyright © 2010 John Wiley & Sons, Ltd.

Multiple imputation using chained equations: Issues and guidance for practice

Statistics for Spatial Data.

Convergence of Probability Measures. By P. Billingsley. Chichester, Sussex, Wiley, 1968. xii, 253 p. 9 1/4“. 117s.

Convergence of Probability Measures

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Modern Applied Statistics With S

We derive an estimator of the asymptotic variance of both single and multiple imputation estimators. We assume a parametric imputation model but allow for non- and semiparametric analysis models. Our variance estimator, in contrast to the estimator proposed by Rubin (1987), is consistent even when the imputation and analysis models are misspecified and incompatible with one another.

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Inference for imputation estimators

There has been substantial recent interest in non- and semiparametric methods for longitudinal or clustered data with dependence within clusters. It has been shown rather inexplicably that, when standard kernel smoothing methods are used in a natural way, higher efficiency is obtained by assuming independence than by using the true correlation structure. It is shown here that this result is a natural consequence of how standard kernel methods incorporate the within-subject correlation in the asymptotic setting considered, where the cluster sizes are fixed and the cluster number increases. In this paper, an alternative kernel smoothing method is proposed. Unlike the standard methods, the smallest variance of the new estimator is achieved when the true correlation is assumed. Asymptotically, the variance of the proposed method is uniformly smaller than that of the most efficient working independence approach. A small simulation study shows that significant improvement is obtained for finite samples.

Marginal nonparametric kernel regression accounting for within‐subject correlation

We consider the asymptotic behaviour of various parametric multiple imputation procedures which include but are not restricted to the 'proper' imputation procedures proposed by Rubin (1978). The asymptotic variance structure of the resulting estimators is provided. This result is used to compare the relative efficiencies of different imputation procedures. It also provides a basis to understand the behaviour of two Monte Carlo iterative estimators, stochastic EM (Celeux & Diebolt, 1985; Wei & Tanner, 1990) and simulated EM (Ruud, 1991). We further develop properties of these estimators when they stop at iteration K with imputation size m. An application to a mcasurement error problem is used to illustrate the results.

Large-sample theory for parametric multiple imputation procedures

DNA microarray technologies, such as cDNA and oligonucleotide microarrays, promise to revolutionize biological research and further our understanding of biological processes. Due to the complex nature and sheer amount of data produced from microarray experiments, biologists have sought the collaboration of experts in the analytical sciences, including statisticians, among others. However, the biological and technical intricacies of microarray experiments are not easily accessible to analytical experts. One aim for this review is to provide a bridge to some of the relevant biological and technical aspects involved in microarray experiments. While there is already a large literature on the broad applications of the technology, basic research on the technology itself and studies to understand process variation remain in their infancy. We emphasize the importance of basic research in DNA array technologies to improve the reliability of future experiments.

DNA Microarray Experiments: Biological and Technological Aspects

We consider marginal generalized semiparametric partially linear models for clustered data. Lin and Carroll derived the semiparametric efficient score function for this problem in the multivariate Gaussian case, but they were unable to construct a semiparametric efficient estimator that actually achieved the semiparametric information bound. Here we propose such an estimator and generalize the work to marginal generalized partially linear models. We investigate asymptotic relative efficiencies of the estimators that ignore the within-cluster correlation structure either in nonparametric curve estimation or throughout. We evaluate the finite-sample performance of these estimators through simulations and illustrate it using a longitudinal CD4 cell count dataset. Both theoretical and numerical results indicate that properly taking into account the within-subject correlation among the responses can substantially improve efficiency.

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Naisyin Wang

Papers

Inference for imputation estimators

Marginal nonparametric kernel regression accounting for within‐subject correlation

Large-sample theory for parametric multiple imputation procedures

DNA Microarray Experiments: Biological and Technological Aspects

Efficient Semiparametric Marginal Estimation for Longitudinal/Clustered Data