The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13878/full. G protein-coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors

Asymmetric domino reactions. Part B: Reactions based on the use of chiral catalysts and biocatalysts

Vinyl epoxides in organic synthesis.

Rh(III)-catalyzed halogenation of vinylic C-H Bonds: rapid and general access to Z-halo acrylamides.

Catalytic friedel-crafts acylation reactions using hafnium triflate as a catalyst in lithium perchlorate-nitromethane

Alkylation of Cyclic 1,3-Diketones

A facile method for the synthesis of 2-cyclopentenones from the acid catalysed fragmentation of 7,7-dimethoxy 5-norbornen-2-ols and their derivatives is reported.

Acid catalyses fragmentation of 7,7-dimethoxy norborneols. A rapid entry to 5-substituted 2-cyclopentenones

Lithium perchlorate/diethyl ether - induced rearrangement of epimeric endo- and exo- dicyclopentadienyl vinyl ethers

Formal [1,3] rearrangement of 2-furylmethyl and 2-thienylmethyl vinyl ethers

We wish to report a facile method in which a catalytic amount of bis-tri- n -butyltinoxide (TBTO) in the presence of sodium borohydride efficiently brings about the intramolecular radical cyclization of a variety of vinyl, aryl and alkyl halides to their corresponding functionalized bicyclic and tricyclic carbocycle frameworks. The methodology obviates the need for stoichiometric amounts of tin reagent normally required for radical cyclization reactions.

/pdf/intramolecular-radical-cyclization-of-vinyl-aryl-and-alkyl-4qigvum14n.pdf

Intramolecular Radical Cyclization of Vinyl, Aryl and Alkyl Halides Using Catalytic Amount of Bis-tri-n-butyltin Oxide/Sodium Borohydride: A Novel Entry to Functionalized Carbocycles

Namasivayam Palani

Papers

Alkylation of Cyclic 1,3-Diketones

Acid catalyses fragmentation of 7,7-dimethoxy norborneols. A rapid entry to 5-substituted 2-cyclopentenones

Lithium perchlorate/diethyl ether - induced rearrangement of epimeric endo- and exo- dicyclopentadienyl vinyl ethers

Formal [1,3] rearrangement of 2-furylmethyl and 2-thienylmethyl vinyl ethers

Intramolecular Radical Cyclization of Vinyl, Aryl and Alkyl Halides Using Catalytic Amount of Bis-tri-n-butyltin Oxide/Sodium Borohydride: A Novel Entry to Functionalized Carbocycles