Nandi Simpson

TL;DR: The disrupted transmission of maternal Bacteroides strains, and high-level colonization by opportunistic pathogens associated with the hospital environment (including Enterococcus, Enterobacter and Klebsiella species), in babies delivered by caesarean section are reported.

TL;DR: It is found that the small GTPase Rac is essential for the matrix-induced changes in endothelial cell morphology, whereas p21-activated kinase, an effector of Rac, is required for cell motility.

TL;DR: It is found that EspF, EspG, and EspH are not required for efficient colonization of the mouse colon or for the production of hyperplasia, and a novel secreted protein, EspI encoded outside the LEE, whose secretion is also dependent on a functional type III secretion system.

TL;DR: It is reported that the immunoglobulin superfamily member CD147 (also called extracellular matrix metalloproteinase inducer (EMMPRIN) is a critical host receptor for the meningococcal pilus components PilE and PilV, and interfering with this interaction potently inhibited the primary attachment ofMeningococci to human endothelial cells in vitro and prevented colonization of vessels in human brain tissue explants ex vivo.

TL;DR: During the course of infection, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC) subvert the host cell signalling machinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes.