M
Mark D. Stares
Researcher at Wellcome Trust Sanger Institute
Publications - 36
Citations - 4965
Mark D. Stares is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 15 publications receiving 3778 citations.
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Journal ArticleDOI
Dominant and diet-responsive groups of bacteria within the human colonic microbiota.
Alan W. Walker,Jennifer Ince,Sylvia H. Duncan,Lucy M. I. Webster,Grietje Holtrop,Xiaolei Ze,David Stanley Brown,Mark D. Stares,Paul Scott,Aurore Bergerat,Petra Louis,Freda M McIntosh,Alexandra M. Johnstone,Gerald E. Lobley,Julian Parkhill,Harry J. Flint +15 more
TL;DR: Time courses obtained by targeted qPCR revealed that ‘blooms’ in specific bacterial groups occurred rapidly after a dietary change, and these were rapidly reversed by the subsequent diet.
Journal ArticleDOI
Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation
Hilary P. Browne,Samuel C. Forster,Samuel C. Forster,Samuel C. Forster,Blessing O. Anonye,Nitin Kumar,B. Anne Neville,Mark D. Stares,David Goulding,Trevor D. Lawley +9 more
TL;DR: A novel workflow based on targeted phenotypic culturing linked to large-scale whole-genome sequencing, phylogenetic analysis and computational modelling demonstrates that a substantial proportion of the intestinal bacteria are culturable and reveals how a marked proportion of oxygen-sensitive intestinal bacteria can be transmitted between individuals, affecting microbiota heritability.
Journal ArticleDOI
Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice
Trevor D. Lawley,Simon Clare,Alan W. Walker,Mark D. Stares,Thomas R. Connor,Claire Raisen,David Goulding,Roland Rad,Fernanda Schreiber,Cordelia Brandt,Laura J. Deakin,Derek Pickard,Sylvia H. Duncan,Harry J. Flint,Taane G. Clark,Julian Parkhill,Gordon Dougan +16 more
TL;DR: A rational approach to harness the therapeutic potential of health-associated microbial communities to treat C. difficile disease and potentially other forms of intestinal dysbiosis is demonstrated.
Journal ArticleDOI
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth
Yan Shao,Samuel C. Forster,Samuel C. Forster,Samuel C. Forster,Evdokia Tsaliki,Kevin Vervier,Angela Strang,Nandi Simpson,Nitin Kumar,Mark D. Stares,Alison Rodger,Peter Brocklehurst,Nigel Field,Trevor D. Lawley +13 more
TL;DR: The disrupted transmission of maternal Bacteroides strains, and high-level colonization by opportunistic pathogens associated with the hospital environment (including Enterococcus, Enterobacter and Klebsiella species), in babies delivered by caesarean section are reported.
Journal ArticleDOI
A human gut bacterial genome and culture collection for improved metagenomic analyses.
Samuel C. Forster,Samuel C. Forster,Samuel C. Forster,Nitin Kumar,Blessing O. Anonye,Blessing O. Anonye,Alexandre Almeida,Alexandre Almeida,Elisa Viciani,Mark D. Stares,Matthew Dunn,Tapoka T. Mkandawire,Ana Zhu,Yan Shao,Lindsay J. Pike,Thomas J. Louie,Hilary P. Browne,Alex L. Mitchell,B. Anne Neville,Robert D. Finn,Trevor D. Lawley +20 more
TL;DR: The improved resource of gastrointestinal bacterial reference sequences circumvents dependence on de novo assembly of metagenomes and enables accurate and cost-effective shotgun metagenomic analyses of human gastrointestinal microbiota.