N
Nitin Kumar
Researcher at Wellcome Trust Sanger Institute
Publications - 52
Citations - 3718
Nitin Kumar is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 18, co-authored 43 publications receiving 2387 citations. Previous affiliations of Nitin Kumar include Universidad Mayor & University of York.
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Journal ArticleDOI
Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation
Hilary P. Browne,Samuel C. Forster,Samuel C. Forster,Samuel C. Forster,Blessing O. Anonye,Nitin Kumar,B. Anne Neville,Mark D. Stares,David Goulding,Trevor D. Lawley +9 more
TL;DR: A novel workflow based on targeted phenotypic culturing linked to large-scale whole-genome sequencing, phylogenetic analysis and computational modelling demonstrates that a substantial proportion of the intestinal bacteria are culturable and reveals how a marked proportion of oxygen-sensitive intestinal bacteria can be transmitted between individuals, affecting microbiota heritability.
Journal ArticleDOI
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth
Yan Shao,Samuel C. Forster,Samuel C. Forster,Samuel C. Forster,Evdokia Tsaliki,Kevin Vervier,Angela Strang,Nandi Simpson,Nitin Kumar,Mark D. Stares,Alison Rodger,Peter Brocklehurst,Nigel Field,Trevor D. Lawley +13 more
TL;DR: The disrupted transmission of maternal Bacteroides strains, and high-level colonization by opportunistic pathogens associated with the hospital environment (including Enterococcus, Enterobacter and Klebsiella species), in babies delivered by caesarean section are reported.
Journal ArticleDOI
A human gut bacterial genome and culture collection for improved metagenomic analyses.
Samuel C. Forster,Samuel C. Forster,Samuel C. Forster,Nitin Kumar,Blessing O. Anonye,Blessing O. Anonye,Alexandre Almeida,Alexandre Almeida,Elisa Viciani,Mark D. Stares,Matthew Dunn,Tapoka T. Mkandawire,Ana Zhu,Yan Shao,Lindsay J. Pike,Thomas J. Louie,Hilary P. Browne,Alex L. Mitchell,B. Anne Neville,Robert D. Finn,Trevor D. Lawley +20 more
TL;DR: The improved resource of gastrointestinal bacterial reference sequences circumvents dependence on de novo assembly of metagenomes and enables accurate and cost-effective shotgun metagenomic analyses of human gastrointestinal microbiota.
Journal ArticleDOI
DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome
Kate J. Howell,Kate J. Howell,Judith Kraiczy,Komal Nayak,Marco Gasparetto,Alexander Ross,Claire Lee,Tim N. Mak,Bon-Kyoung Koo,Nitin Kumar,Trevor D. Lawley,Anupam Sinha,Philip Rosenstiel,Robert Heuschkel,Oliver Stegle,Matthias Zilbauer +15 more
TL;DR: For example, this paper analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis.
Journal ArticleDOI
Culturing of female bladder bacteria reveals an interconnected urogenital microbiota.
Krystal Thomas-White,Samuel C. Forster,Samuel C. Forster,Samuel C. Forster,Nitin Kumar,Michelle Van Kuiken,Catherine Putonti,Mark D. Stares,Evann E. Hilt,Travis K. Price,Alan J. Wolfe,Trevor D. Lawley +11 more
TL;DR: W Whole-genome phylogenetic analysis of bacterial strains isolated from the vagina and bladder in the same women identifies highly similar Escherichia coli, Streptococcus anginosus, and Lactobacillus iners, suggesting an interlinked female urogenital microbiota that is not only limited to pathogens but is also characteristic of health-associated commensals