Showing papers by "Nanette H. Bishopric published in 2016"
TL;DR: A conserved hypoxia-responsive Lin28-miR-let-7-Pik3ip1 regulatory axis is specific to cardiac myocytes and promotes apoptosis during myocardial ischemic injury.
41 citations
TL;DR: The Editors are pleased to present the inaugural edition of JACC: Basic to Translational Science, which questions the need for a journal dedicated to bringing the fruits of fundamental science to translational science.
13 citations
01 Jan 2016
TL;DR: This chapter will provide an overview of the major classes of mammalian KATs: GNAT, p300/CBP, MYST, and the nuclear receptor coactivators, including CLOCK.
Abstract: The lysine acetyltransferases (KATs) are enzymes that catalyze the reversible acetylation of lysine residues within histones, transcription factors, and other proteins. These dynamic and signal-responsive enzymes allow a single pool of nuclear DNA to be interpreted in multiple ways, to create many different cell types, and to carry out a broad range of specialized cell functions. KATs play a particularly important role in adapting the long-lived cells of the cardiovascular system to environmental challenges and changing metabolic states. This chapter will provide an overview of the major classes of mammalian KATs: GNAT, p300/CBP, MYST, and the nuclear receptor coactivators, including CLOCK. Several additional KATs that to date have not been structurally analyzed will also be considered. Special attention will be paid to the role of the KATs in human genetic disorders and in processes important to cardiac and vascular biology.
3 citations
TL;DR: In this article, the authors proposed a method to solve the problem of the problem: the one-dimensional graph of time complexity of the graph of a single node.Corresponding Author
1 citations