N
Naoki Kimura
Researcher at Tokyo Medical and Dental University
Publications - 58
Citations - 2261
Naoki Kimura is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 18, co-authored 51 publications receiving 2159 citations. Previous affiliations of Naoki Kimura include Chugai Pharmaceutical Co..
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Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.
Kinichi Nakashima,Makoto Yanagisawa,Hirokazu Arakawa,Naoki Kimura,Tatsuhiro Hisatsune,Masahiro Kawabata,Kohei Miyazono,Tetsuya Taga +7 more
TL;DR: In this paper, the formation of a complex between STAT3 and Smad1, bridged by p300, is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neural progenitors.
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Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation
Kinichi Nakashima,Stefan Wiese,Makoto Yanagisawa,Hirokazu Arakawa,Naoki Kimura,Tatsuhiro Hisatsune,Kanji Yoshida,Tadamitsu Kishimoto,Michael Sendtner,Tetsuya Taga +9 more
TL;DR: The data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytesin vivo.
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BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6.
TL;DR: It is demonstrated that BMP2 dose-dependently induces apoptosis in MH60 cells even in the presence of IL-6, and it is shown that MH60-derived transfectants expressing Smad6 are resistant to the apoptotic signal of BMP1, suggesting that Smad 6 is likely to function as a negative regulator of the TAK1 pathway in the B MP2 signaling, in addition to the previously reported Smad pathway.
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ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1
Yuichi Hirata,Naoki Kimura,Koh Sato,Yoshiyuki Ohsugi,Shin Takasawa,Hiroshi Okamoto,Jun Ishikawa,Tsuneyasu Kaisho,Katsuhiko Ishihara,Toshio Hirano +9 more
TL;DR: The establishment of a stable transformant CHO cell line which secretes truncated human soluble BST‐1 is reported, and it is shown that purified soluble BST-1 displays both ADP ribosyl cyclase cADPR hydrolase activities.
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Entactin-2: a new member of basement membrane protein with high homology to entactin/nidogen.
TL;DR: The results suggest that entactin-2 is a member of theEntactin gene family, may have entactIn-related functions, and might act as a basement membrane component.