H
Hiroshi Shibuya
Researcher at Tokyo Medical and Dental University
Publications - 94
Citations - 14394
Hiroshi Shibuya is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Wnt signaling pathway & MAP kinase kinase kinase. The author has an hindex of 49, co-authored 89 publications receiving 13883 citations. Previous affiliations of Hiroshi Shibuya include Graduate University for Advanced Studies & National Institute for Basic Biology, Japan.
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Journal ArticleDOI
Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction
Kyoko Yamaguchi,Kyoko Shirakabe,Hiroshi Shibuya,Kenji Irie,Isao Oishi,Naoto Ueno,Tadatsugu Taniguchi,Eisuke Nishida,Kunihiro Matsumoto +8 more
TL;DR: Results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.
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The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway
Isao Oishi,Hiroaki Suzuki,Nobuyuki Onishi,Ritsuko Takada,Shuichi Kani,Bisei Ohkawara,Ikure Koshida,Kentaro Suzuki,General Yamada,Georg C. Schwabe,Stefan Mundlos,Hiroshi Shibuya,Shinji Takada,Yasuhiro Minami +13 more
TL;DR: This work has shown that Ror2 possesses an extracellular cysteine‐rich domain (CRD) that resembles the Wnt‐binding sites of the Frizzled (Fz) proteins, and it is conceivable that ROr2 interacts with members of the WNT family.
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The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
Tohru Ishitani,Jun Ninomiya-Tsuji,Shln Ichl Nagai,Michiru Nishita,Marc D. Meneghini,Nick Barker,Marian L. Waterman,Bruce Bowerman,Hans Clevers,Hiroshi Shibuya,Kunihiro Matsumoto +10 more
TL;DR: It is shown that TAK1 activation stimulates NLK activity and downregulates transcriptional activation mediated by β-catenin and TCF, which negatively regulates the Wnt signalling pathway.
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TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction
Hiroshi Shibuya,Kyoko Yamaguchi,Kyoko Shirakabe,Akane Tonegawa,Yukiko Gotoh,Naoto Ueno,Kenji Irie,Eisuke Nishida,Kunihiro Matsumoto +8 more
TL;DR: Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-β, and increased the kinase activity of TAK1.
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TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
Giichi Takaesu,Satoshi Kishida,Atsushi Hiyama,Kyoko Yamaguchi,Hiroshi Shibuya,Kenji Irie,Jun Ninomiya-Tsuji,Kunihiro Matsumoto +7 more
TL;DR: The identification of TAB2 is reported, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6 and as a mediator of Tak1 activation in theIL-1 signaling pathway.