N
Naoki Shirata
Researcher at Tohoku University
Publications - 3
Citations - 153
Naoki Shirata is an academic researcher from Tohoku University. The author has contributed to research in topics: Gene & Epigenomics. The author has an hindex of 3, co-authored 3 publications receiving 123 citations. Previous affiliations of Naoki Shirata include Iwate Medical University & Tokyo Institute of Technology.
Papers
More filters
Journal ArticleDOI
Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides
Teigo Asai,Kento Tsukada,Satomi Ise,Naoki Shirata,Makoto Hashimoto,Isao Fujii,Katsuya Gomi,Kosuke Nakagawara,Eiichi Kodama,Yoshiteru Oshima +9 more
TL;DR: This work has developed a semi-synthetic process that combines heterologous biosynthesis and artificial diversification of fungal polyketide intermediates and demonstrated an advanced method of using biosynthetic intermediates.
Journal ArticleDOI
Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression.
Teigo Asai,Takashi Yamamoto,Naoki Shirata,Tohru Taniguchi,Kenji Monde,Isao Fujii,Katsuya Gomi,Yoshiteru Oshima +7 more
TL;DR: Epigenetic manipulation of gene expression in Chaetomium indicum using a HDAC inhibitor led to the isolation of structurally diverse chaetophenols, and 3, 4 and 5 bear unprecedented polycyclic skeletons.
Journal ArticleDOI
Structural diversity of new C13-polyketides produced by Chaetomium mollipilium cultivated in the presence of a NAD(+)-dependent histone deacetylase inhibitor.
Teigo Asai,Shuntaro Morita,Naoki Shirata,Tohru Taniguchi,Kenji Monde,Hiroaki Sakurai,Tomoji Ozeki,Yoshiteru Oshima +7 more
TL;DR: Spectroscopic methods, X-ray single crystal diffraction analysis, and VCD elucidated the absolute configurations of structures 1-6, and plausible biosynthetic pathways for 1-7 were proposed based on structural relationships.